2022 NFL Week 1 Odds and Schedule: Colts Open as Biggest Favorite
After a couple of weeks of slowly leaking matchups one at a time, the NFL finally announced the complete schedule for the 2022 NFL Season on Thursday, May 12. Shortly thereafter, sportsbooks started posting Week 1 Spread, Total, and Moneyline Odds. These odds will definitely change over the next few months, but bettors who can accurately project the directions of these teams may be able to get favorable odds for these September matchups in May.
Oddly enough, the Indianapolis Colts opened as the biggest favorite of Week 1. DraftKings Sportsbook has the Colts as a 7.5 point favorite over the Houston Texans for their Week 1 matchup in Houston.
Check out all of our updated consensus odds to win Super Bowl LVII >>
What is Betting Against the Spread?
Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Packers face the Bears, and oddsmakers set the spread at Packers -6.5, you would need Green Bay to win by 7 or more points in order to cash your Packers bet.
See below for the complete consensus odds for the first week of NFL action.
2022 NFL Week 1 Odds
|
THU SEP 8TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|---|---|---|---|
|
8:20PM
BUF Bills
|
+1
-115
|
O 52
-110
|
-110
|
|
LA Rams
|
-1
-105
|
U 52
-110
|
-110
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|---|---|---|---|
|
1:00PM
BAL Ravens
|
-4.5
-110
|
O 45
-110
|
-195
|
|
NY Jets
|
+4.5
-110
|
U 45
-110
|
+165
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
PHI Eagles
|
-4
-110
|
O 46.5
-110
|
-190
|
|
DET Lions
|
+4
-110
|
U 46.5
-110
|
+160
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
NE Patriots
|
+3
-110
|
O 45
-110
|
+135
|
|
MIA Dolphins
|
-3
-110
|
U 45
-110
|
-155
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
PIT Steelers
|
+6.5
-110
|
O 45
-110
|
+200
|
|
CIN Bengals
|
-6.5
-110
|
U 45
-110
|
-250
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
SF 49ers
|
-6.5
-110
|
O 42.5
-110
|
-275
|
|
CHI Bears
|
+6.5
-110
|
U 42.5
-110
|
+220
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
JAX Jaguars
|
+4
-110
|
O 44.5
-110
|
+160
|
|
WAS Commanders
|
-4
-110
|
U 44.5
-110
|
-190
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
NO Saints
|
-3.5
-110
|
O 42
-110
|
-180
|
|
ATL Falcons
|
+3.5
-110
|
U 42
-110
|
+155
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
IND Colts
|
-7.5
-115
|
O 44.5
-110
|
-380
|
|
HOU Texans
|
+7.5
-105
|
U 44.5
-110
|
+290
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
1:00PM
CLE Browns
|
-3.5
-110
|
O 42.5
-110
|
-180
|
|
CAR Panthers
|
+3.5
-110
|
U 42.5
-110
|
+155
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
4:25PM
NY Giants
|
+6.5
+100
|
O 44
-110
|
+235
|
|
TEN Titans
|
-6.5
-120
|
U 44
-110
|
-300
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
4:25PM
KC Chiefs
|
-3
-115
|
O 53
-110
|
-150
|
|
ARI Cardinals
|
+3
-105
|
U 53
-110
|
+130
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
4:25PM
GB Packers
|
-1.5
-110
|
O 49
-110
|
-120
|
|
MIN Vikings
|
+1.5
-110
|
U 49
-110
|
+100
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
4:25PM
LV Raiders
|
+4
-110
|
O 52
-110
|
+155
|
|
LA Chargers
|
-4
-110
|
U 52
-110
|
-180
|
|
SUN SEP 11TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|
8:20PM
TB Buccaneers
|
-2.5
-110
|
O 51.5
-110
|
-135
|
|
DAL Cowboys
|
+2.5
-110
|
U 51.5
-110
|
+115
|
|
MON SEP 12TH
|
SPREAD
|
TOTAL
|
MONEYLINE
|
|---|---|---|---|
|
8:20PM
DEN Broncos
|
-4
-110
|
O 41
-110
|
-190
|
|
SEA Seahawks
|
+4
-110
|
U 41
-110
|
+160
|
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Mike Maher is an editor and content manager at FantasyPros and BettingPros. For more from Mike, check out his archive, follow him on Twitter @MikeMaher, and visit his Philadelphia Eagles blog, The Birds Blitz.