2025 NFL Combine Betting Guide: Top Prop Bets for PrizePicks & Underdog (Saturday)

The NFL Combine is in full swing this week. There's nothing better than watching future stars of the NFL perform in Indy while sweating some 40-yard dash times. Andrew Erickson and Derek Brown share their favorite combine props to smash on PrizePicks and Underdog immediately.

Prizepicks $5 for $50

2025 NFL Combine Betting Guide: Top Prop Bets

QB Jalen Milroe under 4.42 (PrizePicks)

One of the best traits that Jalen Milroe possesses is his legs.

The Alabama quarterback knows he can do wonders for his draft stock with a strong athletic performance on Saturday. That should start with a strong outing in the 40-yard dash.

– Andrew Erickson

RB TreVeyon Henderson under 4.41 (PrizePicks / Underdog)

Per Reel Analytics, Henderson is projected to run a 4.39-4.41 40-yard dash at the NFL Combine. The fact that he has also been clocked over 21 mph numerous times leads me to smash the under for Henderson's 40-yard time. The former Buckeye ranked tenth in breakaway run rate last year (per PFF) and should have no problem breaking some stopwatches in Indy.

– Derek Brown

Dylan Sampson over 4.39 (Underdog)

Yes, I know Sampson reportedly ran a 4.32 40 in high school. No, I'm not crazy for betting the over for his 4.39. Hear me out. Sampson was clocked at 22-23 mph per Catapult. I couldn't find a published run per Reel Analytics with Sampson eclipsing 21 mph. Reel Analytics also published their top 10 projected 40-yard dash times for running backs, with the highest time coming in at 4.43 (Bayshul Tuten).

Sampson didn't find his name inside the top 10. There are moments in Sampson's film where he is caught behind by defenders on long runs and has had higher than a 36.4% breakaway run rate over the last two collegiate seasons. There's enough uncertainty in the analytics and the film to avoid the public consensus and hit the over for Sampson.

– Derek Brown

WR Isaiah Bond under 4.32 (PrizePicks)

If there is any WR that can run the fastest 40-yard dash and usurp Arian Smith as the fastest, it's Isaiah Bond. The Texas WR is one of the fastest WRs in this year's draft class. Like Smith, he has a prolific track background. University of Texas coaches told Sports Illustrated, Albert Breer, that Bond will run in the 4.2-second range in Indy. He also thinks highly of himself to blaze the track on Saturday.

– Andrew Erickson

Omarion Hampton under 4.46 (Underdog)

Hampton's line looks high. Per Reel Analytics, he has been the author of numerous runs of at least 21 mph. Hampton's GPS times have been stout, and per Reel Analytics, he is projected to run between 4.42-4.44 in the 40-yard dash. Hampton could easily coast under this number in Indy.

– Derek Brown

RB Jaydon Blue under 4.36 (Underdog / PrizePicks)

Trust the process (and very confident RBs and WRs from Texas).

– Andrew Erickson

RB Quinshon Judkins under 4.51 (PrizePicks / Underdog)

According to Reel Analytics, the Ohio State RB hit a top-end speed of 21.1 mph in Week 4, which projects to a 4.44-4.46 40-yard dash time. Quinshon Judkins has previously been indicated to have run a 4.49 on his record.

**Update: Judkin’s line has moved to 4.46 on Prizepicks and Underdog. At those these values, I would avoid this bet unless it moves back to the 4.5 range.*

– Andrew Erickson

Bonuses

  • WR Tre Harris UNDER 4.51 (PrizePicks) – AE/DB
  • WR Nick Nash OVER 4.49 (Prizepicks) – AE

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