49ers vs. Cardinals: NFL Week 15 Odds & Picks (2023)
Gear up for another weekend of NFL action! Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at 49ers vs. Cardinals.
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NFL Odds, Picks & Predictions: 49ers vs. Cardinals
49ers vs. Cardinals
Remember when the 49ers lost a couple of games, the football world was telling them to pack it in? Well, they've now won five straight by an average margin of 25.2 points. Brock Purdy has gone from Mr. Irrelevant to MVP consideration as this well-balanced offense runs like a machine. Then you add the defense, and they are championship caliber. The Cardinals got Kyler Murray back, but this team is much better. Standing at 3-10, this team will have a high draft pick and decisions for their future will be made. San Fransisco has put that losing streak behind and they roll through this game.
Pick: 49ers -12.5 (-110)
-John Supowitz
What is Betting Against the Spread?
Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.
What is an Over/Under Bet?
Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.
What is a Moneyline Bet?
A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.
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