49ers vs. Jaguars: NFL Week 10 Odds & Picks (2023)

Gear up for another weekend of NFL action! Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at 49ers vs. Jaguars.

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NFL Odds, Picks & Predictions: 49ers vs. Jaguars

49ers vs. Jaguars

The 49ers desperately needed a bye week last weekend. San Francisco began the season with six straight wins, and it seemed like the team would never lose. However, the Niners dealt with some injuries and lost three straight games while scoring only 17 points in all those matchups. The defense is still electric. The secondary and pass rush will always be hard to beat for offenses. But Brock Purdy and the offense need to figure out how to score more points. With the Jaguars allowing 263.5 yards per game in the air, Purdy should be able to find receivers open. He just needs to be more accurate, like he was throughout the entire start of his career. After all, Jacksonville still has a very reliable secondary that can make plays. On the other hand, Trevor Lawrence only has nine touchdown passes this season. That's not entirely impressive. The defense of the Jaguars has been one of the main reasons for Jacksonville's five-game winning streak.

Pick: Under 45.5

-Jason Radowitz


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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