49ers vs. Rams: NFL Week 2 Odds & Picks (2023)
Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at 49ers vs. Rams.
Go premium to view top prop bets based on Cover Probability, Expected Value & Star Rating >>
NFL Odds, Picks & Predictions: 49ers vs. Rams
The Rams surprised everyone with a 30-13 win over the Seahawks in Week 1. The Rams are without Cooper Kupp, but Puka Nacua and Tutu Atwell stepped up with a combined 16 receptions and nearly 240 yards receiving. Those two could have big years for the Rams if Kupp misses the entire season. But it won't happen against the 49ers. San Francisco's got the best defense in the league and showed out against the Steelers, earning multiple three-and-outs in a 30-7 win. Brock Purdy would love an offensive line that could block better. But he's got a lot of talent around him. Purdy needs to limit turnovers and get the ball to his playmakers, like Christian McCaffrey. With that said, I'll take the Under. Los Angeles won't be nearly as good offensively in this game.
Pick: Under 44.5 (-110)
-Jason Radowitz
What is Betting Against the Spread?
Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.
What is an Over/Under Bet?
Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.
What is a Moneyline Bet?
A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.
Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts
Whether you're new to sports betting or a betting pro, our Sports Betting Strategy and Advice page is for you. You can get started with our 101 section - including 10 Sports Betting Tips for Beginners - or head to more advanced strategy - like Key Numbers When Betting Against the Spread - to learn more.