After a relatively low-key first weekend of March Madness hoops, we are back in action tonight as the Sweet 16 kicks off. Despite no major Cinderellas becoming the tournament darlings and only one double-digit seed making it to the second weekend, we have a plethora of fantastic matchups to look forward to.

These No. 1 seeds are the best grouping of top seeds in the history of KenPom, but it's no guarantee they will all make it to San Antonio. We have four games tonight, and today is my favorite option of the two Sweet Sixteen days. I've had Maryland-Florida circled since the bracket dropped. But let's get right into previewing each game with some leans and best bets.

2025 NCAA Tournament March Madness Bracket Strategy & Betting Picks>>

NCAA Tournament Best Sweet 16 Bets

No. 2 Alabama Crimson Tide vs. No. 6 BYU Cougars

Location: Prudential Center – Newark, NJ
Line: Alabama -5.5 | Total: 175.5

The Sweet Sixteen matchup between Alabama and BYU promises to be an offensive spectacle that could quickly become the tournament’s most interesting game. Having this game kick off the day’s action is a privilege. Both teams bring explosive offensive capabilities with remarkably similar profiles: high-scoring attacks and porous defenses. BYU has been particularly impressive since February, averaging 130.4 points per 100 possessions, while Alabama brings its trademark rapid transition game and ability to score quickly. Both squads sit in the top-10 in KenPom offensive efficiency for the season.

The game will likely be decided by which team handles missed shots more effectively, with both squads boasting impressive records when establishing early leads. Notably, they have a combined 45-1 record when up by 10 points, suggesting that the first team to create separation might be difficult to catch. It stands out that BYU's ability on the defensive glass outpaces Alabama, and their transition defense should hold up, allowing just 10 total transition points in this tournament and ranking outside the top 300 in defensive possession rate. This should be an awesome game for which you should get the popcorn, but Bama is laying too many points and is due for a dud game with their low field goal attempt rate. Sprinkle some dough on BYU ML, but the play is the underdog.

Bet: BYU +5.5 (-110 at BetMGM)

No. 1 Florida Gators vs. No. 4 Maryland Terrapins

Location: Chase Center – San Francisco, CA
Line: Alabama -6.5 | Total: 157

Next up we have what I hope is the game of the tournament. Both teams have relied heavily on three-point shooting variance, with Florida hitting +8% and Maryland an even more impressive +12.5% on three-pointers compared to their season average during their recent run, per Will Warren. The game may hinge on the turnover battle, with Maryland’s defensive pressure potentially disrupting Florida’s offensive rhythm. Surprisingly, this is just the fourth team that Florida faces with a top-45 turnover rate all year. Their previous games resulted in high turnover rates and a relatively struggling offense for the powerhouse the Gators have become. Facing Tennessee thrice gives Florida preparation for an elite defense but they faced only one other top-10 defense all year. On the otherside, Florida boasts one of the best perimeter defenses in the league and should bring Maryland down to earth offensively. I do expect Maryland to keep this one tight but simply cannot fade Florida. Instead, I'm riding the under for what should be a defensive affair.

Bet: Under 157.5 Points (-115 at BetMGM)

No. 4 Arizona Wildcats vs. No. 1 Duke Blue Devils

Location: Prudential Center – Newark, NJ
Line: Duke -9.5 | Total: 153.5

We've already seen this one before with the Blue Devils having already defeated Arizona earlier this season by 14 points in a game that exposed significant Wildcat vulnerabilities. Arizona’s potential path to victory here rests heavily on the unpredictable shooting performance of Caleb Love, who would need to replicate his recent Oregon game, going 5-7 from deep. Duke’s ability to generate quick scoring runs and exceptional rim defense make them a formidable opponent, with Jon Scheyer's squad consistently demonstrating they can dismantle the best defensive schemes. I don't expect Tyrese Proctor to go 7-8 from three, and Duke to shoot 54%, but they still boast the best offense in the game. While Arizona boasts talent and has transformed their frontcourt since the first matchup, they face an uphill battle against a Duke team that appears to be hitting its stride at the perfect moment in the tournament. I would bet alts here with Arizona's dependence on Love in a matchup against Duke. Obviously, there's a lot on the line, and I view this game as a one-possession battle where Arizona has a lucky shooting night, or Duke wins by 20, as they've done. No official play here but I'm expecting the latter.

Lean: Duke -9.5 (-108 at FanDuel Sportsbook)

No. 10 Arkansas Razorbacks vs. No. 3 Texas Tech Red Raiders

Location: Chase Center – San Francisco, CA
Line: Texas Tech -5.5 | Total: 148

Finally, we have the arguably least interesting game starting at an insanely late time for my liking, but that's neither here nor there. The Red Raiders enter as the more consistent offensive threat, boasting an exceptional catch-and-shoot game and the ability to create quality looks, while the Razorbacks rely on transition play and defensive disruption to overcome their halfcourt offensive struggles. Arkansas has transformed throughout the season, and Boogie Fland and potentially Adou Thiero returning adds a dynamic element that hasn't previously been accounted for. The game’s outcome will hinge on Arkansas’ ability to generate turnovers and fast-break opportunities. But Texas Tech allows transition offense at the 313th lowest rate in the country, which is not great for Arkansas. Tech will need to shoot at least below average from the perimeter to win this, and if they shoot anything above average, it's game over for Arkansas. I'm banking on Arkansas' offense struggling while Texas Tech gets plenty of looks from three and rides this game to the Elite Eight.

Bet: Texas Tech -5.5 (-105 at Caesars Sportsbook)