Bengals vs. 49ers: NFL Week 8 Odds & Picks (2023)

Gear up for another weekend of NFL action! Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at Bengals vs. 49ers.

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NFL Odds, Picks & Predictions: Bengals vs. 49ers

Bengals vs. 49ers

I took the Bengals +3.5 once news broke that Brock Purdy was in concussion protocol, but the line has jumped up to as high as +4.5 in some spots with word that Purdy was present at practice Thursday. I'm still operating under the assumption that Sam Darnold will make the start Sunday, as teams have been far more conservative with the concussion protocol this season. But even if Purdy plays, I still like the Bengals to keep this game within a field goal, if not win outright. I suspect Joe Burrow is at or awfully close to full strength after the bye. Meanwhile, it's the 49ers who are dealing with a bevy of injuries, as there's a decent chance both Trent Williams and Deebo Samuel miss this game too. Burrow and the Bengals are 13-6 ATS as a road underdog, and I like the spot for Cincinnati coming off of its bye week against a 49ers team that played last Monday night. This feels like a hard-nosed defensive game that Cincinnati keeps close the entire way.

Pick: Bengals +5

-Matt Barbato


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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