Cardinals vs. Commanders: NFL Week 1 Odds & Picks (2023)

Sunday marks the first full slate of NFL games for the 2023 season. Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at Cardinals vs. Commanders.

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NFL Week 1 Odds, Picks & Predictions: Cardinals vs. Commanders

Cardinals vs. Commanders

Joshua Dobbs will start for the Cardinals in Week 1. We might never see Kyler Murray start for the Cardinals again, even when he returns to the field after recovering from an ACL tear. Arizona looks like one of the worst teams in the NFL this year. They even lost J.J. Watt to retirement. The defense was terrible against the run last season and average in the passing game. However, I think Washington's offense will surprise some folks this year. The Commanders are riding out this season with Sam Howell, and he's got a lot of great playmakers around him. It's unclear if Terry McLaurin will play in Week 1. But even if he doesn't, Jahan Dotson will step up. Plus. Washington's secondary was outstanding last season. Dobbs won't have much success throwing the football when Arizona finds itself down. Take the Commanders at -7.

Pick: Commanders -7 (-110)


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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