Chargers vs. Colts: NFL Week 16 Early Odds, Picks & Predictions (2022)

Week 15 saw some of the craziest finishes of the 2022 season.

On Saturday, the Minnesota Vikings erased a 33-point deficit to win the NFC North and break the record for the biggest comeback in NFL history. On Sunday, the Jacksonville Jaguars beat the Dallas Cowboys in overtime. The Detroit Lions took down the New York Jets for their sixth win in seven games, and the New England Patriots may have lateralled their way out of a postseason against the Las Vegas Raiders. 

Here is a look at some early Week 16 lines and where you should expect them to move. And here’s a closer look at Chargers vs. Colts.

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Chargers vs. Colts: NFL Week 16 Early Odds, Picks & Predictions (2022)

How does a team rebound from what the Colts went through in Week 15? After leading 33-0 at halftime, they fell 39-36 in overtime, and they now have to play against the red-hot Chargers on “Monday Night Football.”

The Chargers are 3.5-point road favorites. Though the Colts are getting the hook, expect this number to grow throughout the week. After such a demoralizing loss, and with the Chargers finally playing up to their potential, this game has blowout written all over it, even if it’s being played in Indianapolis.

Current Line: Chargers -3.5

Predicted Final Line: Chargers -4.5

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