College Football Parlay Picks for Week 12 (2021)

Time sure does fly when you are having fun, which has been precisely the case during this college football season. We are already into Week 12, which leaves just two regular-season cards left before Championship Weekend. This week's NCAAF slate is a doozy. Conference standings will continue rounding into form, the playoff picture figures to grow a bit clearer, and there are even a few rivalry games on deck one week early. With so much action, we have plenty of options at our disposal when compiling this week's college football betting parlays.

The following article outlines two featured college football parlay picks for Week 12. Additional wagers are included at the end of the column for those who wish to mix and match beyond the pre-constructed parlay bets.  

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Week 12 Featured College Football Parlay #1

Our first featured parlay ticket for Week 12 includes five money line wagers. Four picks involve favorites, while one late-night underdog to win outright serves as the key bet for beefing up the odds. These five outright picks combine to form a parlay with +317 odds. Let's examine each bet in greater detail.

Michigan State at Ohio State (-1000)

The Buckeyes have done very little to show that they are head and shoulders above the rest of the Big Ten Conference this season. Last week was an exception to that as OSU rolled to a 28-point win and ATS cover over Purdue. I lean towards Ryan Day's squad covering the spread again this week. For the sake of this parlay, we'll settle for an outright Buckeyes win. The Spartans do not have the defensive pieces to contend with the lethal Ohio State receiving trio of Garrett Wilson, Chris Olave, and Jaxson Smith-Njigba.

BYU (-1200) at Georgia Southern

Several weeks ago, this might have had the makings of a trap game for BYU. It's hard to imagine the Cougars will get caught looking ahead towards a USC squad that is nowhere near the team as advertised. They will have little trouble with a Georgia Southern team that has won just two Sun Belt Conference games on the season to date.

Auburn (-275) at South Carolina

With quarterback Bo Nix getting knocked out of last week's game with an injury, Auburn is a shorter betting favorite than they would have been on the road in Columbia this week. The Tigers still should be able to do enough offensively with T.J. Finley under center to outscore an awful Carolina outfit.

Oklahoma State (-450) at Texas Tech

Night games in Lubbock, Texas, have a knack for getting wild and wacky. Oklahoma State has a conference championship sitting out in front of them and a potential berth in the College Football Playoff. All the Pokes have to do is win out.

Mike Gundy's team has one of the best defenses the Big 12 has seen in years. They should be able to dictate things against a Texas Tech squad coming off an emotional upset last week.

Colorado State at Hawaii (+110)

We head out to the Hawaiian islands for some late-night Mountain West action to wrap up this five-leg college football betting parlay. It's no secret that Hawaii has one of the most difficult travel schedules of any FBS team. However, the Rainbow Warriors at home compared to on the road this season has been night and day. In the friendly confines of Aloha Stadium, Hawaii successfully stunned Fresno State and played a ranked San Diego State team to a seven-point game. On the road, Todd Graham's team has struggled. Most recently, they lost to a miserable UNLV program just last week. 

Meanwhile, Colorado State brings zero momentum into this game, having lost four straight. The wrong side is favored, and we'll look to use the plus-money opportunity on Hawaii to our advantage in this parlay.

Check out all of our college football game previews and picks of the week >>

Week 12 Featured College Football Parlay #2

This second featured parlay is a bit smaller in size than the first, with only three legs. However, two of those picks deal with sports betting's great equalizer, the point spread. As a result, the relative risk remains about the same as our first parlay despite two fewer bets. Together, the two ATS picks and a Big Ten moneyline favorite result in a parlay ticket with +336 odds.

UCLA (-3) at USC 

The battle for the coveted Victory Bell is a rivalry game played a week early compared to the rest of the college football world. USC has primarily owned the city of Los Angeles in recent seasons, having won five of the last six head-to-head meetings against UCLA. However, Chip Kelly has brought an element of stability to the Bruins program that the currently coachless Trojans do not have. Think again if you think UCLA forgot about last year's tough loss to their in-city rivals. 

Other than a seven-point win over an awful Arizona team, the Trojans have not beaten any other Pac-12 opponents at home all season. The Bruins will be out to prove something on Saturday night. Dorian Thompson-Robinson and Zach Charbonnet should run all over the beleaguered USC defense. 

SMU at Cincinnati (-10.5)

After failing to cover the spread again last week against a very bad South Florida team, Luke Fickell and Cincinnati are running out of time to prove they belong in the College Football Playoff. Perhaps they have been saving up their best effort for this week's highly-anticipated showdown against SMU. Although the Mustangs no longer are unbeaten in the standings, they bring the No. 1 scoring offense in the American Conference to Historic Nippert Stadium on Saturday. This is the perfect opportunity for the Bearcats' defense to rise up and shut down Tanner Mordecai and the SMU attack. 

This line has moved in the Mustangs' favor throughout the week. However, it has held firm at UC -11 across the entire Las Vegas market. Shop around for the best number you can find. A half-point could be the difference between winning and losing this parlay ticket.

Purdue (-450) at Northwestern

Jeff Brohm and the Boilermakers will be on a mission to bounce back after getting taken to the woodshed by Ohio State last week. That game marked just the second conference loss of the season for Purdue, who still has an outside chance of sneaking into the Big Ten title game. Although Northwestern has allowed the third-fewest passing yards per game in the conference, no one has been able to stop David Bell all season. The Wildcats won't be the first defense to pull that off.

Other Week 12 College Football Bets to Consider

While the three featured parlays above have been constructed for you, the beauty is that bettors can mix and match to build their parlays as they wish. Not feeling convinced by any of the picks above? Looking to create an even bigger parlay? This section is for you! Below are a few additional college football bets to consider for Week 12. Good luck with all of your NCAAF wagers this week, and enjoy the games!

Moneyline Favorites of Various Degrees 

Kent State (-600)
Tulane (-200)
Coastal Carolina (-2000)
Alabama (-1600)
Utah State (-200)

Moneyline Underdogs with Bite 

Iowa State (+145)
Illinois (+375)
Navy (+160)
Missouri (+260)
Oregon (+135)

Point Spread Plays 

Illinois (+12.5)
Colorado (+7)
Nebraska (+8.5)
Kansas State (-1)

Over/Under Options 

Wake Forest at Clemson (Over 56.5)
Florida at Missouri (Over 69.5)
Oregon at Utah (Under 58.5)

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Henry John is a featured writer at BettingPros. For more from Henry, check out his archive and follow him @HankTimeHenry.

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