College Football Week 10 Odds, Picks & Predictions (2024)

Gear up for another awesome weekend of college football action with BettingPros! We’ll have you covered with all of our top picks for the week along with our projected spreads and totals to help guide your college football bets. Below are our top picks and predictions for this week’s college football games.

Top College Football Odds & Picks: Week 10

Air Force vs. Army

Air Force already took it on the chin against Navy in its first try against the other service academy, and now it will try to slow Army. The Falcons have really had tremendous difficulty on offense this season, going for 19 or fewer points in five of six games against FBS opponents. The only team Air Force had a modicum of success against was New Mexico, a team with a shabby defense. The Falcons have allowed 31 or more points in four of the past five games, too. Oh, and did we mention Air Force is 0-7 against the spread (ATS) this season? Army, on the other hand, has been a juggernaut. The Black Knights have posted 37 or more points in six of seven games, including a 45-28 whitewashing of East Carolina last time out on Oct. 19. Army is coming off a bye, so it will be rested and raring to go. Army is No. 1 in the country with 359.1 rushing yards per game, and it averages 40.4 PPG to check in 9th in the nation. Defensively, Army is very good, too, and perhaps that doesn’t get talked about enough. It allows just 281.9 total yards and 12.4 points per game. While USAFA is 0-7 ATS, Army is quite the opposite at 6-1 ATS this season. Back the Knights.

Pick: Army -22 

-Daniel Dobish


Florida vs. Georgia

This is certainly not the same Gators we saw in September. The defense is better, especially with gaining turnovers; they've won the turnover margin in the last four games and have five in the previous two. The defense will have to be on point because they will be one-dimensional; Montrell Johnson and Jadan Baugh will need to be on point because DJ Lagway has just one game with over 100 passing yards against an FBS opponent. That was against Kentucky, which is 20th in passing yards allowed, and Georgia is 39th. It will depend on whether we see vintage Carson Beck. Although the Bulldogs came away with the win against Texas, he threw for 175, zero touchdowns, and three interceptions. He now has eight interceptions in the last four games, and Florida has forced an interception in three straight games. Florida is playing with confidence and they will get Georgia off guard with that defense.

Pick: Florida +14.5

-John Supowitz


Oregon vs. Michigan

Oregon has that No. 1 spot for the second week in a row, and they look much different from the start of the season. Some parts were struggling; the offensive line allowed pressure, the run game wasn't working, and they relied on explosive plays. They have fixed all those problems, and Dillion Gabriel is now leading the Heisman odds. Last year, this would been the game to watch, but this isn't the same Michigan team that won the championship. They have zero passing, as they are 129th in passing yards per game. They are still a solid defense, but they are not used to playing in from behind and added time on the field due to the offense not having prolonged possessions. We already saw Texas be able to come and put up points, Oregon should do the same.

Pick: Oregon -14.5

-John Supowitz


Ohio State vs. Penn State

Both teams really need this win to remain at the forefront of the CFP race. Ohio State's offense has calmed down since conference play has gotten underway, but the unit is still averaging 30+ (relative to 50+ in non-conference games). It is hard to say how much offense they'll generate against a solid Penn State defense, but they may not need much against Penn State, especially if Drew Allar doesn't play or is limited. The Nittany Lions do not blow up the scoreboard but score around 30+ points while the defense shuts down the opposing offense. If Allar is out, take the Buckeyes to win; the Buckeyes defense will eat Penn State's QB2 alive. But if Allar does play, look for this to be a hard-fought, low-scoring game.

Pick: Under 47.5

-Travis Pulver


Duke vs. Miami

The Blue Devils head down to South Florida looking to bounce back after a stunning 28-27 OT loss to SMU last week in Durham despite being plus-6 in the turnover department. This is a Manny Diaz revenge special, too, as he was unceremoniously dumped in favor of Mario Cristobal by the Miami program, so he’ll likely be pulling out all of the stops to derail the season of the top-5 Hurricanes. Diaz was fired on Dec. 6, 2021, and replaced by Cristobal that day. So you know Diaz has an ax to grind here. Miami’s offense has been prolific with QB Cam Ward at the helm, while Duke has been less impressive with QB Maalik Murphy, although he is the best bet for an upset. The Duke defense is fierce, allowing just 166.6 passing yards per game to rank 12th in the land. But Ward and WR Xavier Restrepo will certainly put that to the test. Miami should be able to get the job done at home, but Duke catching three touchdowns in a revenge game for its coach is quite a bit.

Pick: Duke +21

-Daniel Dobish


Kentucky vs. Tennessee

Tennessee has had a couple of weeks to reflect on their big win against Alabama. The run game has been the strongest part of their offense, and Dylan Sampson has been even better recently, averaging 129.6 yards over his last three games. This is also one of the best defenses in the nation, allowing 11.5 points per game. Kentucky looked like they had momentum after that win against Ole Miss, but they are coming in, losing three straight and the last two by a combined 42 points. The offense hasn't been great all year, but now the defense has been struggling, the components that were able to beat at the time No. 6 Ole Miss and nearly No. 1 Georgia aren't there against non-ranked opponents. You have to like a well-rested Vols team getting it done.

Pick: Tennessee -17.5

-John Supowitz


Louisville vs. Clemson

A big-time ACC matchup takes center stage at Clemson on Saturday. The Tigers have looked like one of the best teams in the country after their Week 1 loss to Georgia. QB Cade Klubnik has led the way with 10.8 YPA in the air during this six game win streak. This has propelled the offense to 48.5 PPG, scoring 40+ in all but one game during the streak. Louisville comes into this game with some strong offensive numbers themselves. The Cardinals have posted 31.6 PPG in conference play, including a 45-point performance against Miami, where they racked up 448 yards of offense and gave the ninth-ranked EPA defense a difficult task. To go with these elite offenses you have two defenses that rank closer to the middle of the pack of the ACC by some advanced metrics. Although the total is pretty high in the low 60s, it may not be high enough. This should be an offensive explosion.

Pick: Over 62

-Ryan Rodeman


Texas Tech vs. Iowa State

Iowa State will look to continue its march toward the Big 12 title game against a Texas Tech team that could be entering freefall mode. The Red Raiders have dropped two straight, a 24-point loss at Baylor followed by a 1-point loss to TCU. It’s fair to wonder where Tech will be emotionally coming into Ames. There are also massive concerns for the Red Raiders defense, which ranks outside the top 100 nationally in both passing and rushing defense. It also could be tough sledding for the Tech offense. The Red Raiders rank eighth nationally in passing attempts and 19th in passing yards per game, but will go up against an elite Iowa State secondary that ranks second nationally in pass defense. Factor in that Iowa State is off a bye while Texas Tech is hitting the road for the second straight week, and this has the potential to get ugly.

Pick: Iowa State -13.5

-Matt Barbato


Indiana vs. Michigan State

It still feels strange to use the word 'good' when talking about Indiana football, but the Hoosiers have an excellent football team. They can run and throw the ball well, they have one of the most efficient passing offenses in the country, they rarely turn the ball over, and they have the No. 2 scoring offense in the country. Okay, so they've made a name for themselves primarily off dominating lesser teams. But they have done just that, not letting one of these weaker teams come close to getting a win. As for Michigan State, they struggle to generate offense, but their defense is okay. However, it will be on the field so much that it will get tired, allowing IU to pull away with this one in the end.

Pick: Indiana -7.5

-Travis Pulver


Texas A&M vs. South Carolina

If this was still the Jimbo Fisher Era, the call for this game would be easy-take South Carolina's ML. When everything is going A&M's way, the Aggies tend to flop against an opponent they should beat. But what will they do in the Mike Elko Era? That's a good question and a hard one to answer without knowing who starts at quarterback this week: Weigman or Reed? South Carolina's strength is its defense, which has been tough against the pass and run. But the Gamecocks offense is dreadful, and A&M's defense should get it off the field quickly on most drives. Texas &M will be good on offense no matter who starts at QB, and the defense will take care of business against South Carolina.

Pick: Texas A&M -3

-Travis Pulver


Kansas State vs. Houston

The Cougars picked up a 17-14 win over Utah last week, and they’re now winners of two of their last three. However, this is still a team that has scored more than 20 points just twice all season. Additionally, they have one of the worst run defenses in the country, allowing 168.8 rushing yards per game. The Wildcats have the 10th-best rushing offense in the nation, and they’re going to run all over the Cougars on Saturday. With so few possessions, the inefficient Houston offense will struggle more than usual against a defense allowing just 23.6 points per game. Because of all of this, the Wildcats will cover this surprisingly low spread.

Pick: Kansas State -13 

-Phil Wood


Ole Miss vs. Arkansas

Ole Miss, as usual since Lane Kiffen took over, has one of the better offenses in the country (No. 7 total yards). But unlike some past teams that were fantastic at throwing the ball, this one can throw (No. 4) and run No. 40). But while the numbers look good overall, they have gone down since conference play began, and the Rebels had to play competitive games. But what they aren't good at is stopping the pass and throwing the ball is something the Razorbacks do well (No. 23). Ole Miss has a solid run defense, but I don't think it is really the best in the country; the stats are skewed due to an incredibly easy non-conference schedule. It may not happen until the second half, but the Razorbacks will pound the Ole Miss defense into submission.

Pick: Arkansas ML (+240)

-Travis Pulver


Pittsburgh vs. SMU

Pittsburgh and SMU have a combined record of 14-1, but neither team has beaten an opponent that is currently ranked in the AP Top 25. The Mustangs are the home team, and despite being responsible for the one loss between these two, they’re favored by 7.5 points. These teams are very evenly matched across the board, averaging almost the same exact total yards per game, while the defenses are each ranked in the top 50 in the country in yards allowed. With the spread a true toss-up, the Over becomes the right play. The number is set at 56.5, and both of these teams are averaging over 35.5. points per game. While both defenses have been solid this season, they’re not used to playing offenses as good as the ones they’ll face this weekend.

Pick: Over 56.5

-Phil Wood


TCU vs. Baylor

This game features two offenses averaging over 30 points per game going up against two defenses allowing over 29 points per game. That’s a recipe for a shootout. The Bears have given up at least 28 points in five consecutive games while scoring at least 28 in all but one of those contests. The Horned Frogs have scored fewer than 20 points in two of their last three games, but they managed 35 last week against Texas Tech. Their defense has allowed at least 27 points in six of their seven games against FBS teams. Both offenses have had some trouble against good defenses this season. The good news for them is that they won’t be going against good defenses this week.

Pick: Over 63.5

-Phil Wood

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