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College Football Week 12 Odds, Picks & Predictions: Duke vs. Pittsburgh (2022)

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Let’s take a look at the College Football Week 12 odds, picks, and predictions for this weekend’s game: Duke vs. Pittsburgh.

And check out our other game previews and picks for Week 12 of the College Football season:

Check out Thor Nystrom’s Week 12 College Football Power Rankings >>

College Football Week 12 Odds, Picks & Predictions: Duke vs. Pittsburgh

The Blue Devils have been a frequent team of interest in the longshot winners realm, and they've come through for us twice in the season. With the second to last weekend upon us, I'm going to see if they can't come through for us one more time.

This week they match up with Pittsburgh. The Panthers rank 49th in SP+ with a 41st-ranked offense. However, this isn't the same offense that was led by Kenny Pickett in 2021. Their offense was held in check a few times this season, including in losses to Georgia Tech, Louisville, and UNC. Even in the blowout over Virginia this last week, they were spotted 14 points in the opening seconds and managed just 23 points on the next ten drives that didn't result at the end of a half.

Duke has been a scrappy team that's played above their advanced rankings. They'll look for their eighth win of the season in this matchup, their most in eight years. A massively improved defense has changed the complexion of this team. They rank 51st in SP+ and have really shown up in big games.

The offense has also excelled in ACC play. They're outpaced in scoring during conference play by only UNC, Clemson, and Florida State. Led by QB Riley Leonard, in the air, and on the ground, they're more than capable of putting up points on this Pittsburgh team.

This Duke team has not lost a game by more than one possession. Their worst loss came in an 8-point defeat at the hands of a fully healthy Kansas team on the road. There's no reason to believe this team can not only keep this tight but pull out a big road victory.

Pick: Duke ML (+250)

What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

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