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College Football Week 14 Odds, Picks & Predictions (2024)

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Gear up for another awesome weekend of college football action with BettingPros! We’ll have you covered with all of our top picks for the week along with our projected spreads and totals to help guide your college football bets. Below are our top picks and predictions for Week 14 college football games.

Top College Football Odds & Picks: Week 14

Washington vs. Oregon

Oregon played a close game against Wisconsin, but their undefeated season is still intact. Besides remaining perfect, they don't have anything to play for, as they have already clinched a spot in the Big Ten Championship. It wasn't a great performance last game for Dillion Gabriel, who failed to throw a touchdown for the first time this year and now gets a Washington pass defense that's fifth in passing yards allowed (160.5). However, the Huskies are beginning to fade, as they've allowed an average of 263 passing yards over their last three games. Their biggest problem is they cannot score; even with a 1,000-yard rusher in Jonah Coleman and an experienced quarterback like Will Rogers, they are 109th in points scored (22.9). Even if Washington could play to their defensive potential, they will have trouble scoring against an outstanding Oregon defense.

Pick: Oregon -18.5

-John Supowitz

Notre Dame vs. USC

For the first time in nearly two months, Notre Dame will travel out of state for a true road game. USC will host the Fighting Irish in another installment of their longstanding rivalry. Notre Dame held up their end of the bargain as a CFP contender but stumbles and a QB change along the way for USC has them 6-5 and looking to just play spoilers. However, they’re pretty talented spoilers. Notre Dame played a schedule that was devoid of elite offenses. Some of the most effective passing games like Georgia Tech (269 yards and 7.1 YPA) and Louisville (264 yards and 6.4 YPA) had success on this Irish defense but either couldn’t get the run game going or defense let them down. USC has been a successful offense this year. They averaged 285.5 YPG in the air and that’s helped them amass 29.3 PPG on the season. They have some firepower to be able to challenge this strong Notre Dame defense that really hasn’t been tested much to this point. With no conference championship to help pad their resume, this is Notre Dame’s last chance to make their CFP case. USC would love nothing more than to end those dreams on Saturday afternoon in Los Angeles. They should give the Irish a scare and maybe even pull off the upset.

Pick: USC +7.5

-Ryan Rodeman

Florida vs. Florida State

Florida is riding high after becoming bowl-eligible thanks to upset home victories over LSU and Ole Miss. And while going bowling might sound like a disappointing year for the Gators, it’s actually quite an accomplishment if you take a look at their schedule. Now, Florida will get a chance to punctuate a regular season in which it defied expectations against a Florida State team that just won its second game of the season… over Charleston Southern. Billy Napier’s offense is predicated on the ground game, which is great news against a Florida State run defense that ranks 106th nationally in rushing yards allowed per game. The Seminoles have won the last two matchups, so revenge should be on the minds of the Gators as they head into Tallahassee, which I’m guessing won’t have the same juice considering how bad the Noles have been this season. Florida gets revenge in a big way.

Pick: Florida -16.5

-Matt Barbato

Michigan vs. Ohio State

This game has been one of the most anticipated and entertaining of the last three seasons, but don't expect that to be the case this season. Yes, Michigan is the defending national champion, but this team and that team are two wildly different things. Ohio State, on the other hand, is its usual high-powered offense, dominant defense self. The offensive line is banged up, but if it can hold up to Indiana's front seven, it will be fine against Michigan. The Wolverines, however, have struggled on offense all year long and will find it hard to get a first down in this game, let alone points. The spread is massive, but there is no reason to think the Buckeyes can't cover it.

Pick: Ohio State -19.5

-Travis Pulver

Tennessee vs. Vanderbilt

Can Vanderbilt ruin another team’s season? They certainly could make things interesting. The Commodores run a unique, almost service academy type of offense that can be difficult to prepare for. Plus, all of the pressure is riding on the Volunteers, who are most likely in the College Football Playoff field with a win. Don’t let last week’s 56-point outburst against UTEP mislead you, the Volunteers offense hasn’t been great recently, particularly QB Nico Iamaleava. The Tennessee passing game has been inefficient over the last two months and ranks just 64th in passing yards per game. That being said, Vanderbilt likely won’t find much success through the air against a top-30 Vols secondary. And I just worry about the talent disparity in a game with so much on the line. Given the troubles of the Tennessee offense, the under is my preferred play.

Pick: Under 48.5

-Matt Barbato

South Carolina vs. Clemson

This game has major College Football Playoff implications. Clemson is trying to get into the ACC Championship game with some help. On the other hand, South Carolina has won five consecutive games, including wins over Texas A&M, Vanderbilt, and Missouri. In addition, this is a big rivalry game. Clemson has the advantage at home, but South Carolina has the edge analytically. Which one matters more? The Gamecocks have allowed just 18.18 points per game and have one of the best pass defenses in college football. They've held teams to just 200.27 yards and have an elite pass rush along with an elite secondary. While Clemson might not have the best pass rush, there's a better chance the Tigers will get through South Carolina's weaker offensive line. Cade Klubnik has been really good at limiting turnovers. If South Carolina starts with poor field position throughout the game, the home crowd will be a factor, too. Therefore, I'm backing the home team in a super-tight matchup.

Pick: Clemson -2.5

-Jason Radowitz

Miami vs. Syracuse

The Miami Hurricanes need a win to earn an ACC Championship spot. The Hurricanes put themselves in this predicament by losing to Georgia Tech on November 9. That said, Miami has Cam Ward at quarterback, who will likely be a top-three finalist for the Heisman Award this season. He's thrown for 3,774 yards and 34 touchdowns and has helped Miami to 44.73 points per game this season. The Hurricanes are one of the most electric offenses in college football. However, don't sleep on Syracuse. The Orange have scored 31.73 points per game themselves and are 8-3 on the season. Behind Kyle McCord, Syracuse could potentially win ten games this season. McCord doesn't have as many touchdowns as Ward, but he's got nearly 4,000 yards passing. This game should be a shootout. Let's take the Over 67.5.

Pick: Over 67.5

-Jason Radowitz

Auburn vs. Alabama

A week ago, there would have been little to talk about regarding this game. Alabama would control the game from beginning to end and win easily. But then the Bama offense couldn’t do anything right against an ‘okay’ Oklahoma defense, and Auburn absolutely dominated an excellent Texas A&M defense. Jalen Milroe and the Alabama offense will not likely play as poorly as they did vs. the Sooners ever again. But Auburn running back Jarquez Hunter could have a day against the Tide’s defense. A week ago, I’d have said Bama would blow the Tigers out. This week– it’s going to be a closer game than expected.

Pick: Auburn +10.5

-Travis Pulver

California vs. SMU

Who would ever have thought Cal and SMU would be an important game in the Atlantic Coast Conference? Man, college football in 2024, you’re so weird. Cal has already secured bowl eligibility with a win over rival Stanford in last week’s “Big Game”, but it could really improve its bowl position with a victory over a 10-win SMU side. The Mustangs are on their way to the ACC Championship Game, but they have eyes on a much bigger prize. SMU likely needs a win here, and maybe next week in the ACC Championship Game, to secure a spot in the College Football Playoffs. This program was once handed the Death Penalty by the NCAA for paying players. These days, the money SMU paid in the mid-1980s wouldn’t even be the NIL fund for a Sun Belt Conference team. SMU QB Kevin Jennings is the big man on campus in Big D these days, throwing for 2,521 yards and 17 TDs, while running for 315 and four more scores. RB Brashard Smith is also a stud, going for 1,089 and 13 TDs, doing his best Craig James or Eric Dickerson impression. The Mustangs are worth a look laying the points, as they look to keep the hammer down in their pursuit of a CFP berth.

Pick: SMU -13.5

-Daniel Dobish

Arkansas vs. Missouri

The Arkansas Razorbacks are 3-4 in conference play but just 1-5 against AP Top 25 teams. They'll take on the Missouri Tigers, who are currently ranked 21. The Tigers have been much more competitive since Brady Cook returned to the lineup as the starting quarterback. Cook helped Missouri to 30 points in a 34-30 loss to South Carolina and then quarterbacked them to 39 points against Mississippi State in a win. He should have a field day against an Arkansas secondary that has given up more than 250 passing yards per game this season. Don't expect either team to earn a high rushing-yard rate. But in the passing game, Cook will make a lot of quality plays. Take Missouri at home at -3.

Pick: Missouri -3

-Jason Radowitz

Oklahoma vs. LSU

The Sooners are coming off a massive win over Alabama, while the Tigers ended a three-game losing streak by defeating Vanderbilt 24-17. The Tigers are only favored by six in this game, and that feels like a massive overreaction to the Sooners’ performance last week. While that game was impressive, especially defensively, as they held the Crimson Tide to just three points, the Sooners have been demolished by SEC opponents this season. They lost by 31 to Texas and 26 to South Carolina, and all five of their SEC losses have been by at least 10 points. The Tigers aren’t playing their best football right now, but had Oklahoma lost last week, this spread would likely be double-digits. Take the Tigers in a letdown spot for the Sooners.

Pick: LSU -6

-Phil Wood

Texas vs. Texas A&M

After 13 long years, one of the greatest rivalries in college football is back! Winning the game gives both a direct line to the CFP (although Texas A&M would also need to win the SEC title game). But more importantly, winning means bragging rights. Texas comes into the game with a high-profile, injured quarterback. A&M has an extremely bruised ego after losing a winnable game in 4OT vs. Auburn last weekend. The Longhorn offense is capable of exploiting the A&M defense much in the same way Auburn did. Texas A&M needs to do a better job of embracing Marcel Reed's athleticism. The Aggies will get a boost from playing in front of 100K+ fans at home, but it's not like Texas hasn't played in hostile territory before. A&M tends to lose focus and make dumb mistakes, resulting in costly penalties. Texas has played the softest schedule in the SEC. So, just how good are these guys? Texas will either win big or Texas A&M will win by one score, but it could easily go either way. However the game finishes, we don't think either defense will have a ton of success.

Pick: OVER 48.5

-Travis Pulver

Purdue vs. Indiana

I love a good, old-fashioned trophy. Purdue and Indiana play for the Old Oaken Bucket in Saturday’s tilly at The Rock in Bloomington. The Hoosiers are licking their wounds after suffering their first loss of the season at Ohio State in a top-5 battle Indiana certainly looked ready for primetime at first, firing out to a 7-0 lead, but they struggled to keep QB Kurtis Rourke upright, and they committed way too many miscues for a game of that magnitude, and things started to snowball. Indiana will look to take its day out on poor ol’ Purdue, but the Hoosiers won’t have any sympathy for their biggest rivals. The Boilermakers are a dismal 1-10, and that lone victory came against Indiana State of the FCS back on Aug. 31. Purdue has scored 17 or fewer points in six of the past eight games, while allowing 35 or more points in five of the past seven. There just aren’t a lot of bright spots. Purdue has won three in a row in this series, and five of the past six outings, but this Indiana team is the best in that school’s history, and it is angry after last week’s loss in Columbus. Look for a 49-6 kind of a game, if Purdue even scores at all.

Pick: Indiana -29

-Daniel Dobish

Houston vs. BYU

After starting the season 9-0, BYU have lost back-to-back games, and the Cougars are now in danger of missing out on the Big 12 Championship. What’s been most disappointing for the Cougars over the last three weeks is their offense. They’re averaging 29.8 points per game this season, but they’ve scored 23 or fewer points in three consecutive weeks. This week, they face a Houston defense allowing just 22.3 points per game. But for as good as Houston’s defense has been, the Cougars’ offense is tied for the third-worst in the nation. They’re averaging just 13.6 points per game, and they will likely struggle to get over that number against a BYU defense allowing just 21.0 points per game. With BYU playing poorly on the offensive side of the ball, it’s hard to imagine this game going Over, even though this total is very low.

Pick: Under 41 

-Phil Wood

Louisville vs. Kentucky

It’s been a disastrous season for the Wildcats so it’s shocking to see them only underdogs of four points in this game. Yes, this game is being played in Lexington, but that’s the only advantage that the Wildcats have. They can’t earn bowl eligibility with a win, so is this a trap from oddsmakers or just an overreaction to the assumed talent of the SEC? I’m going with the latter. The Wildcats have lost five of their last six games, and their only win was against Murray State. Meanwhile, the Cardinals have won three of their last four games, defeating Clemson 33-21 and destroying Pittsburgh by a final score of 37-9. This spread seems like a gift, as the Cardinals are the much better team this season.

Pick: Louisville -4

-Phil Wood

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