College Football Week 3 Early Odds, Picks & Prediction: Ohio State vs. Toledo (2022)

Let’s take a look at the College Football Week 3 odds, picks, and predictions for this week’s game: Ohio State vs. Toledo.

Check out Thor Nystrom’s Week 3 College Football Power Rankings >>

College Football Week 3 Early Odds, Picks & Prediction: Ohio State vs. Toledo

WR Jaxon Smith-Njigba missed Saturday's blowout victory over Arkansas State with the hamstring injury that knocked him out of the opening-week win over Notre Dame. Smith-Njigba is expected to miss this weekend's game against Toledo, too.

OSU was also without WR Julian Fleming against the Red Wolves. Fleming warmed up before the game against the Fighting Irish and also before Saturday's game against ASU but was unable to play in either. OSU HC Ryan Day expects Fleming back this weekend against Toledo.

With Smith-Njigba down, youngsters Marvin Harrison Jr. (7-184-3) and Emeka Egbuka (4-118-1) each went off against the Red Wolves. Both will get peppered with targets again against Toledo. If Fleming is active, he would give the Buckeyes the legitimate WR3 they didn't have against ASU.

DC Jim Knowles said after the opening-week win over Notre Dame that the Buckeyes played "rather basic" defense that night and that there were a "lot of things we haven't shown." That remained the case after the win over Arkansas State, and will likely be the case after the Toledo game, too.

Expect Knowles to open up his bag of tricks when Big 10 play opens. Early returns on Knowles' unit have been extremely positive, for whatever that's worth.

What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

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