College Football Week 4 Odds, Picks & Prediction: Clemson vs. Wake Forest (2022)

Let’s take a look at the College Football Week 4 odds, picks, and predictions for this week’s game: Clemson vs. Wake Forest.

And check out our other College Football Week 4 game previews and best bets:

• Indiana vs. Cincinnati
• Kentucky vs. Northern Illinois
• Western Kentucky vs. FIU
• Washington vs. Stanford
• Kansas vs. Duke
• Purdue vs. Florida Atlantic
• Boston College vs. Florida State
• Charlotte vs. South Carolina
• Old Dominion vs. Arkansas State
• Central Michigan vs. Penn State
• TCU vs. SMU
• Notre Dame vs. UNC
• Arizona vs. California
• James Madison vs. Appalachian State
• USC vs. Oregon State
• Missouri vs. Auburn
• Maryland vs. Michigan
• Florida vs. Tennessee
• Arkansas vs. Texas A&M
• Wisconsin vs. Ohio State
• Kansas State vs. Oklahoma

Check out Thor Nystrom’s Week 4 College Football Power Rankings >>

College Football Week 4 Odds, Picks & Prediction: Clemson vs. Wake Forest

Wake Forest starts their ACC schedule hosting Clemson. The Demon Deacons come into the game after surviving an upset effort by a scrappy Liberty team in week 3. Giving pause on Wake Forest is understandable, but expect them to come in focused on a Clemson opponent that has been the toast of the ACC for the better part of a decade. QB Sam Hartman was excellent in 2021, but a medical scare right before the season made his football future uncertain. Thankfully, he's back and with two games now under his belt, he will only get more comfortable in the offense.

Clemson's 3-0 record and 41.3 points per game is not indicative of how the offense has actually performed. Week 1 against Georgia Tech, Clemson managed just 13 first-half points, but took advantage of some short fields and poured it on late to make the final score look less pedestrian. Again, in week 3 against Louisiana Tech, they managed just 13 by halftime, but scored often in the second half. However, three of the five touchdown drives came on short fields of 32 yards or less.

Wake Forest will look to show that last season's ACC Championship Game appearance wasn't a fluke. A home win over Clemson will silence any doubters. If Clemson's offense gets off to another slow start, the firepower on the Wake Forest offense may dig too deep of a hole for Clemson to climb out.

Pick: Wake Forest ML (+235)

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