College Football Week 4 Odds, Picks & Prediction: TCU vs. SMU (2022)

Let’s take a look at the College Football Week 4 odds, picks, and predictions for this week’s game: TCU vs. SMU.

And check out our other College Football Week 4 game previews and best bets:

• Indiana vs. Cincinnati
• Kentucky vs. Northern Illinois
• Western Kentucky vs. FIU
• Washington vs. Stanford
• Kansas vs. Duke
• Purdue vs. Florida Atlantic
• Boston College vs. Florida State
• Charlotte vs. South Carolina
• Old Dominion vs. Arkansas State
• Central Michigan vs. Penn State
• Notre Dame vs. UNC
• Arizona vs. California
• Clemson vs. Wake Forest
• James Madison vs. Appalachian State
• USC vs. Oregon State
• Missouri vs. Auburn
• Maryland vs. Michigan
• Florida vs. Tennessee
• Arkansas vs. Texas A&M
• Wisconsin vs. Ohio State
• Kansas State vs. Oklahoma

Check out Thor Nystrom’s Week 4 College Football Power Rankings >>

College Football Week 4 Odds, Picks & Prediction: TCU vs. SMU

TCU Horned Frogs -2 at SMU Mustangs, Total 70.5 

Kickoff: Saturday, noon ET

The main story of this rivalry game will be Sonny Dykes’ return to SMU, where he helped put the program back on the map. And while all eyes might be on the offenses in this game, TCU’s defense deserves the attention.

Led by defensive coordinator Joseph Gillespie, the Horned Frogs’ defense ranks 35th against the run and 73rd against the pass while giving up just 30 points in wins over Colorado and Tarleton State. SMU can certainly score, as they’ve put up 40+ against North Texas and Lamar. Last week, SMU put up 520 yards against Maryland but converted them into just 27 points due to three turnovers. The Terrapins averaged 9.3 yards per pass and nearly six yards per rush.

The Horned Frogs have quickly embraced Dykes’ offensive system, and quarterback Max Duggan threw for 390 yards and five touchdowns in their win over Tarleton State. And TCU’s 19th-ranked running game should have no trouble against SMU, allowing 177 yards per game on the ground.

TCU should have no issues moving the ball and benefit from an extra week of preparation. Bet the Horned Frogs to get the job done.

The pick: TCU Moneyline (-125)

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