College Football Week 4 Odds, Picks & Prediction: USC vs. Oregon State (2022)

Let’s take a look at the College Football Week 4 odds, picks, and predictions for this week’s game: USC vs. Oregon State.

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Check out Thor Nystrom’s Week 4 College Football Power Rankings >>

College Football Week 4 Odds, Picks & Prediction: USC vs. Oregon State

Oregon State hosts PAC-12 rival USC Saturday night in Corvallis, Ore. The Beavers have steadily improved under head coach Jonathan Smith after about a decade of conference irrelevance. They enter this contest 3-0 on the season with a win over Mountain West darling Boise State and a road win over a good Fresno State team.

USC will be the Beavers' toughest test yet. The Trojans boast a top-10 offense by almost any metric and took care of common opponent Fresno State with ease last Saturday. In contrast, Oregon State needed a last-minute score to beat the Bulldogs on the road. Yet, the results against Fresno State are not indicative of where these two teams are currently. In reality, Oregon State boasts a highly-rated offense of their own that is more than capable of scoring on the USC defense. This matchup could end up being a shootout and that is often a recipe for an upset.

With a win in Los Angeles last season, this Beaver squad will not be intimidated by the names on the back or front of the jerseys lined up across from them. Expect Reser Stadium to be rocking for this PAC-12 matchup between high-powered offenses. USC is officially on upset alert.

Pick: Oregon State ML (+205)

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