College Football Week 4 Odds, Picks & Prediction: Virginia vs. Syracuse (2022)

Let’s take a look at the College Football Week 4 odds, picks, and predictions for this week’s game: Virginia vs. Syracuse.

And check out our other Week 4 college football game previews:

Check out Thor Nystrom’s Week 4 College Football Power Rankings >>

College Football Week 4 Odds, Picks & Prediction: Virginia vs. Syracuse

A pair of ACC foes will meet in Syracuse on Friday night, as the undefeated Orangemen will host the 2-1 Cavaliers. For the home team, a dramatic 32-29 win over Purdue last week will have to quickly be put in the rearview, as quarterback Garrett Shrader has a tall task ahead of him with UVA coming to town. With 705 yards through the air and another 202 on the ground, Shrader is quietly building quite the campaign that also includes 11 total touchdowns and zero interceptions.

For Virginia, quarterback Brian Armstrong is again the guy at the helm, though is more of a game manager compared to his counterpart in this matchup. The Cavaliers have relied on their rushing attack to this point, as freshman running back Xavier Brown has led the way with 7.2 yards per game.

While this number has jumped since opening at Syracuse -9, I don't see a scenario in which UVA can keep with the offensive efficiency that Shrader and the Orange put forward.

Pick: Syracuse -10.5

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you’re new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our Sports Betting 101 Section - including 10 Sports Betting Tips for Beginners - or head to more advanced sports betting strategies - like Key Numbers When Betting Against the Spread - to learn more.

Try Premium for FREE in our mobile app