College Football Week 5 Odds Pick & Prediction: Colorado vs. Arizona (2022)

Let’s take a look at the College Football Week 5 odds, picks, and predictions for this week’s game: Colorado vs. Arizona.

Check out our other best college football bets for Week 5:

• Tulane vs. Houston
• San Diego State vs. Boise State
• Washington vs. UCLA
• Alabama vs. Arkansas
• Michigan vs. Iowa
• Kentucky vs. Ole Miss
• LSU vs. Auburn
• Arizona State vs. USC
• NC State vs. Clemson
• Oklahoma State vs. Baylor
• Oklahoma vs. TCU
• UTSA vs. Middle Tennessee State
• Michigan State vs. Maryland
• Northwestern vs. Penn State
• Georgia Southern vs. Coastal Carolina
• UL Monroe vs. Arkansas State
• Florida State vs. Wake Forest
• East Carolina vs. South Florida
• Texas State vs. James Madison
• Texas vs. West Virginia
• Rutgers vs. Ohio State
• Old Dominion vs. Liberty
• New Mexico State vs. FIU

Check out Thor Nystrom’s Week 5 College Football Power Rankings >>

College Football Week 5 Early Odds, Picks & Prediction: Colorado vs. Arizona

Colorado Buffaloes at Arizona Wildcats (-16.5) | Total 57

Kickoff: Saturday, 9:30 ET

Speaking of ugly, how about a bet on the winless Colorado Buffaloes, who have lost every game this season by at least 25 points? Is that something you might be interested in?

Unfortunately, I am interested in backing the Buffs here. Arizona is 2-2 and showing signs of growth as a program in year two under Jedd Fisch. However, the Wildcats haven’t looked like a team that should be laying over two touchdowns in any scenario. Heck, Arizona hasn’t been favored once all season, and that includes a game against FCS power North Dakota State.

The look-ahead line last week was Arizona -10. The current line is an overreaction to Colorado’s 28-point loss to UCLA. Maybe the Buffs really are this awful, but I’m willing to pay to find out.

The pick: Colorado +16.5 (-105 on FanDuel)

What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

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