College Football Week 6 Odds, Picks & Prediction: Iowa vs. Illinois (2022)

Let’s take a look at the College Football Week 6 odds, picks, and predictions for this week’s game: Iowa vs. Illinois.

Here are other game previews for Week 6:

And check out our other Week 6 College Football betting content:

Check out Thor Nystrom’s Week 6 College Football Power Rankings >>

College Football Week 6 Odds, Picks & Prediction: Iowa vs. Illinois

Iowa Hawkeyes at Illinois Fighting Illini -3.5, Total 36.5 

Kickoff: Saturday, 7:30 ET

Who’s ready for a good old-fashioned Big Ten West rock fight? The Illini are coming off a massive road upset against Wisconsin, while Iowa is licking its wounds after a relatively uncompetitive loss to Michigan at home. With everyone in the division except Wisconsin sitting at 1-1, this is a massive game for both teams.

That said, I wouldn’t expect too many fireworks in Champaign. These defenses allow five yards per pass attempt, the top two in the country. The Illini and Hawkeyes also rank top three nationally in scoring defense, with Illinois allowing just 8.4 points per game and Iowa surrendering a measly 10 points per game.

Have I mentioned these offenses rank outside the top 75 in scoring and passing offense? The only respectable facet is the Illinois running game, which ranks 30th nationally. However, they’ll have their hands full against a Hawkeyes front that ranks 13th against the run.

This should be a closely contested game and an entertaining one if you like defensive struggles. These two teams are a combined 3-7 to the under this season and 2-4 in games against Power 5 foes.

The pick: Under 36.5


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

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