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College Football Week 6 Odds, Picks & Prediction: Michigan vs. Indiana (2022)

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Let’s take a look at the College Football Week 6 odds, picks, and predictions for this week’s game: Michigan vs. Indiana.

Here are other game previews for Week 6:

And check out our other Week 6 College Football betting content:

Check out Thor Nystrom’s Week 6 College Football Power Rankings >>

College Football Week 6 Odds, Picks & Prediction: Michigan vs. Indiana

#4 Michigan (-22.5) @ Indiana and OVER 58.5 

We took Michigan last week, and it worked, so we are going to ride again! The most impressive part of the Michigan victory last week to me was the offense dominating Iowa!  Iowa only had 1 sack and no turnovers for a defense that had utterly dominated everyone they played. Michigan had a balanced account that went for over 300 yards, and RB Blake Corum rushed for 133 yards which no team had hit against Iowa before this game. QB J.J. McCarthy was efficient, going 18/24 for 155 yards and a TD.

Michigan did all of this against a top-tier defense in Iowa, and Indiana is on the other end of the scale.  The Indiana defense is giving up an average of 30 points per game, ranks 118th in passing yards allowing 277.8 YPG, and allows over 142 rushing yards per game, ranking 69th. Michigan is 6th in the country in PPG, averaging 45.4 PPG, and are averaging just over 30 PPG in their two games against Power 5 teams (who both have better defenses than Indiana, IMO).

The biggest mismatch in this game is on the other side of the ball. Indiana has been a bit one-sided on offense with a strong passing game, ranking 33rd in the country behind transfer QB Connor Bazelak. The problem is they can't run the ball efficiently, they rank 116th in rushing total and 110th in YPC. The lack of a respectable run game will make 2nd and 3rd long, bad news for an offensive line that ranks in the bottom 15 of pass blocking by PFF's metrics.  Michigan has 15 sacks from 11 different players, and I expect it to be a long day for Bazelak.  Michigan will have to do the heavy lifting on the score, but I see this as a 52-14 or 49-21 type of game that Michigan should dominate!

Pick: Michigan -22.5 (-120) AND Over 58.5 (-110)

What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

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