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College Football Week 6 Odds, Picks & Prediction: Ole Miss vs. Vanderbilt (2022)

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Let’s take a look at the College Football Week 6 odds, picks, and predictions for this week’s game: Ole Miss vs. Vanderbilt.

Here are other game previews for Week 6:

And check out our other Week 6 College Football betting content:

Check out Thor Nystrom’s Week 6 College Football Power Rankings >>

College Football Week 6 Odds, Picks & Prediction: Ole Miss vs. Vanderbilt

#9 Ole Miss (-16.5) @ Vanderbilt and UNDER 61.5

Vanderbilt is a very improved team overall, but they are still at the bottom of the SEC and aren't ready to compete with the top teams in the SEC, as evidenced by the 55-3 beating Bama put on them two weeks ago. Vandy has some dominant wins over Hawai'i, Elon, and Northern Illinois but has been pounded by the two P5 opponents they've played so far in Wake Forest (45-25) and Alabama. Vandy has established itself as a run-first offense behind transfer RB Ray Davis and even ranks top 25 in PFFs run grade.  

Mississippi has been a bit bipolar in run defense this season which has given them middling statistics and grades against the run this season. Tulsa, who beat the spread and made the game close against Ole Miss, ran for 262 yards against Ole Miss. Tulsa ran the ball 43 times and had some big chunk runs of 47 and two of 17, making up 31% of that total.  This doesn't scare me because Ole Miss fixed the issue last week against Kentucky, holding the Wildcats to 108 rushing yards on 37 attempts.

While the run game could be an issue for Ole Miss, the rest of the game is a mismatch.  Ole Miss hasn't been crisp passing the ball, and transfer QB Jaxson Dart has been anything but sharp so far, but Vandy doesn't pressure QBs enough. Vandy only has seven sacks on the season and ranks dead last in pass rush grade from PFF. The biggest issue that Vandy is facing is the Ole Miss run game. The Rebs have a season-low of 186 rushing yards, and that was against a ranked opponent last week in Kentucky. Ole Miss has gone over 300 yards rushing twice, and the only team that Vandy has held to under 150 yards was Hawai'i in Week 1 when they got up 38-10 early in the 3rd, and Hawai'i ended up with 55 pass attempts and only ran 26 times. The extra week to prep might help Vandy for a little bit, but once Ole Miss starts running downhill, they'll be hard to stop. Once again, I'm threading the needle a little bit, laying the points and taking the under, but I think the run-first identity of both teams will lead to burning the clock, and I don't think Vandy will score much at all. I see this as a Rebs Win in the neighborhood of 35-10 or 42-17, which would hit both sides.  The public money is on our side, too, so let's ride with them and add to the W column!

Bet: Ole Miss -16.5 (-115) and Under 61.5 (-106)

What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

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