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College Football Week 6 Odds, Picks & Prediction: Virginia vs. Louisville (2022)

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Let’s take a look at the College Football Week 6 odds, picks, and predictions for this week’s game: Virginia vs. Louisville.

Here are other game previews for Week 6:

And check out our other Week 6 College Football betting content:

Check out Thor Nystrom’s Week 6 College Football Power Rankings >>

College Football Week 6 Odds, Picks & Prediction: Virginia vs. Louisville

This will become my favorite bet of the week if Louisville QB Malik Cunningham is ruled out. But either way, I'm riding with Virginia.

Cunningham suffered an undisclosed injury in Saturday's loss to Boston College. He missed the final two drives in what turned out to be a 34-33 loss as double-digit favorites.

Cunningham is Louisville's entire offense. He leads the Cards in both rushing and passing yards and has accounted for 43.7% and 66.3% of the team's rushing and total yardage.

Cunningham was replaced by QB2 Brock Domann, who went 1-for-7 through the air while not providing any mobility. The downgrade from Domann to Cunningham is arguably worth a TD or more on the spread.

So if Cunningham is out, consider my spread more like UVA -7 or -8. Here was what SI's Louisville blog had to say: "Louisville is capital-S screwed if [Cunningham misses] time." UL HC Scott Satterfield, who is on a seat hotter than the sun's core, has refused to discuss Cunningham's injury or prognosis.

Like Louisville, Virginia has been a "sell" team for us for much of the season. But the Cavs have started to figure things out, namely, how to work around a poor OL. That had also previously been Boston College's bugaboo, but Louisville wasn't exactly able to exploit that. In fact, BC rushed for more yards last week than they had against their past three P5 opponents combined.

Virginia played quality games against ODU and Syracuse last month before succumbing to Duke in a back-to-back road spot last week. I think the Cavs will get back on track by upsetting Louisville.

Pick: UVA +3

What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

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