Cowboys vs. Bills: NFL Week 15 Odds & Picks (2023)

Gear up for another weekend of NFL action! Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at Cowboys vs. Bills.

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NFL Odds, Picks & Predictions: Cowboys vs. Bills

Cowboys vs. Bills

The Cowboys are one of the hottest teams in the league, as they've come in winning eight of their last ten. Dak Prescott has emerged after a rough start to the season, and now his 28 touchdowns lead the league, and the 74.6 QBR is second. The Bills' season has been a roller coaster ride, and now they need to win in order to even have a chance to make the playoffs. Does Josh Allen throw a lot of picks? Yeah, but he also has the most total touchdowns and is third in QBR. It's important to know the Bills' offense would be mediocre if he weren't their quarterback. While each team has talent on the defensive side, both teams possess one of the better offenses in the league. This could turn into an offensive showdown, so look for the over.

Pick: Over 50 (-110)

-John Supowitz


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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