Giants vs. Bills: NFL Week 6 Odds, Picks & Player Prop Bets

I’m Andrew Erickson, and I’m here to guide you through each game on the NFL slate, offering insights and recommendations on sides, totals, and player props that you can quickly turn into a big single-game parlay. Whether you’re a seasoned bettor or just dipping your toes into the world of NFL wagering - I know that I am for the first time now that my state has legalized wagering - this primer is designed to provide you with valuable perspectives and picks for the upcoming NFL week of action. Here are my top picks for Giants vs. Bills.

NFL Betting Primer: Giants vs. Bills

Buffalo Bills (BUF -14.5) vs. New York Giants

When the NFL schedule was released, it didn’t look great for the New York Giants. But man, I don’t think anybody thought it could go THIS bad for Big Blue. Juggernaut after juggernaut they have been tasked with taking on. And to add literal insult to injury – Daniel Jones is dealing with a neck injury – they have to face a pissed-off Buffalo Bills team coming off a loss in London. They just recently faced a pissed-off Miami Dolphins team and were totally overmatched.

As two TD road underdogs, you’d like to think they could at least cover the spread? Well, think again.

Big Blue’s offense – which has played a grand total of two quarters through five games this season – it’s hard to have any confidence they will turn things around. 0-5 versus the spread. Woof.

The team is also extremely banged up between Jones, Andrew Thomas, John Michael Schmitz, Matt Peart, Darren Waller and Wan’Dale Robinson.

The only semblance they have is that maybe Saquon Barkley suits up. But an RB coming off a high ankle sprain can only do so much behind a patchwork OL.

As a result, New York is 4-1 toward the under this season. Just have no faith that this offense can show up in any capacity even against a banged-up Bills defense that has been pretty solid this season.

Woof. Take the Bills, and don’t look back.

New York has trailed by AT LEAST 10-plus points in all five games this season. And we have seen Buffalo TROUNCE teams in all their wins by margins of 28, 28, and 34. 14 points may not be enough against a Tyrod Taylor-led team. Might be worth an alternate spread to get your money’s worth of a potential blood bath.

The Giants’ pressure rate ranks in the bottom 10. And if you can’t get to Josh Allen, he shreds you.

From a total perspective, I am shooting for the under at 45. Even though the Bills are 2-0 toward the over at home, I have no faith that Big Blue can push them into scoring, unless Barkley is active. If Saquon plays, I might be slightly more tempted to shoot for the over, given how bad the Bills run defense has been this season. Again, the only Giants games to go over the totals have been when their offense has shown any pulse. As it stands right now, that doesn’t seem to be the case.

My Picks:

My Props:


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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