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MLB Moneyline, Over/Under, Run Line Odds & Matchups for Thursday (4/21)

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We’ve compiled odds from all of the major US sportsbooks to provide you a range of odds, as well as our consensus odds for today’s slate of MLB action. You can find moneyline, over/under, and run line odds along with each MLB matchup of the day.

What is Betting the Run Line?
The run line is a set of odds bookmakers use to balance out MLB betting action by “handicapping” the favorite while boosting the underdog. The standard run line is 1.5, which means that bettors can choose to bet on the underdog +1.5, or the favorite -1.5. The odds on these wagers are quite different from the straight moneyline odds, with the moneyline underdog turning into the run line favorite.

What is an Over/Under Bet?
Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 8.5 runs and you bet Over, you will need the combined score of both teams to be 9 runs or higher to win your bet.

What is a Moneyline Bet?
A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Cardinals (+1.5) @ Marlins
04/21/22 6:40 PM EDT – MLBN

View Matchup

PARTICIPANTS AND SELECTIONS

CARDINALS
7-3
+1.5
-185
+1.5
-190
+1.5
-210
+1.5
-190
+1.0
-138
+1.5
-185
+1.5
-200
+1.5
-200
+1.5
-200
+1.5
-200

MARLINS
4-7
-1.5
+155
-1.5
+155
-1.5
+172
-1.5
+160
-1.0
+115
-1.5
+155
-1.5
+160
-1.5
+155
-1.5
+160
-1.5
+155

 

Pirates (+1.5) @ Cubs
04/21/22 7:40 PM EDT – MLBN

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PARTICIPANTS AND SELECTIONS

PIRATES
5-7
+1.5
-140
+1.5
-145
+1.5
-152
+1.5
-140
+1.0
+105
+1.5
-140
+1.5
-152
+1.5
-152
+1.5
-152
+1.5
-152

CUBS
6-6
-1.5
+120
-1.5
+120
-1.5
+126
-1.5
+120
-1.0
-125
-1.5
+120
-1.5
+123
-1.5
+123
-1.5
+123
-1.5
+123

 

Rangers (+1.5) @ Mariners
04/21/22 9:40 PM EDT – MLBN

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PARTICIPANTS AND SELECTIONS

RANGERS
2-9
+1.5
-175
+1.5
-185
+1.5
-184
+1.5
-165
+1.0
-133
+1.5
-180
+1.5
-182
+1.5
-182
+1.5
-182
+1.5
-182

MARINERS
7-5
-1.5
+145
-1.5
+150
-1.5
+152
-1.5
+145
-1.0
+110
-1.5
+150
-1.5
+145
-1.5
+145
-1.5
+145
-1.5
+145

 

Giants (+1.5) @ Mets
04/21/22 1:10 PM EDT

View Matchup

PARTICIPANTS AND SELECTIONS

GIANTS
8-5
+1.5
-134
-1.5
+165
+1.5
-210
+1.5
-170
+1.0
-128
+1.5
-185
+1.5
-195
+1.5
-195
+1.5
-200
+1.5
-200

METS
10-4
-1.5
+110
+1.5
-200
-1.5
+172
-1.5
+150
-1.0
+110
-1.5
+155
-1.5
+163
-1.5
+163
-1.5
+160
-1.5
+160

 

White Sox (-1.5) @ Guardians
04/21/22 1:10 PM EDT

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PARTICIPANTS AND SELECTIONS

WHITE SOX
6-6
-1.5
+110
-1.5
+125
-1.5
+125
-1.5
+110
-1.0
-115
-1.5
+110
-1.5
+118
-1.5
+118
-1.5
+117
-1.5
+117

GUARDIANS
7-5
+1.5
-130
+1.5
-150
+1.5
-150
+1.5
-130
+1.0
-105
+1.5
-130
+1.5
-139
+1.5
-139
+1.5
-141
+1.5
-141

 

Yankees (-1.5) @ Tigers
04/21/22 1:10 PM EDT

View Matchup

PARTICIPANTS AND SELECTIONS

YANKEES
7-6
-1.5
-115
-1.5
EVEN
-1.5
-102
-1.5
-115
-1.5
EVEN
-1.5
-110
-1.5
-103
-1.5
-103
-1.5
-103
-1.5
-103

TIGERS
5-7
+1.5
+130
+1.5
-120
+1.5
-118
+1.5
-105
+1.5
-118
+1.5
-110
+1.5
-121
+1.5
-121
+1.5
-121
+1.5
-121

 

Blue Jays (-1.5) @ Red Sox
04/21/22 1:35 PM EDT

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PARTICIPANTS AND SELECTIONS

BLUE JAYS
8-5
-1.5
+133
-1.5
+135
-1.5
+138
-1.5
+140
-1.0
+115
-1.5
+145
-1.5
+133
-1.5
+133
-1.5
+130
-1.5
+130

RED SOX
6-7
+1.5
-160
+1.5
-160
+1.5
-166
+1.5
-160
+1.0
-138
+1.5
-175
+1.5
-157
+1.5
-157
+1.5
-159
+1.5
-159

 

Twins (-1.5) @ Royals
04/21/22 2:10 PM EDT

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PARTICIPANTS AND SELECTIONS

TWINS
5-8
-1.5
+110
-1.0
-115
-1.5
+138
-1.5
+110
-1.0
-115
-1.5
+110
-1.5
+132
-1.5
+132
-1.5
+130
-1.5
+130

ROYALS
5-6
+1.5
-130
+1.0
-110
+1.5
-166
+1.5
-130
+1.0
-105
+1.5
-130
+1.5
-157
+1.5
-157
+1.5
-159
+1.5
-159

 

Orioles (+1.5) @ Athletics
04/21/22 3:37 PM EDT

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PARTICIPANTS AND SELECTIONS

ORIOLES
4-8
+1.5
-150
-1.5
+165
+1.5
-194
+1.5
-180
+1.0
-133
+1.5
-185
+1.5
-200
+1.5
-200
+1.5
-205
+1.5
-205

ATHLETICS
7-6
-1.5
+155
+1.5
-200
-1.5
+160
-1.5
+155
-1.0
+110
-1.5
+155
-1.5
+165
-1.5
+165
-1.5
+165
-1.5
+165

 

Diamondbacks (+1.5) @ Nationals
04/21/22 4:05 PM EDT

View Matchup

PARTICIPANTS AND SELECTIONS

DIAMONDBACKS
4-8
+1.5
-170
+1.5
-190
+1.5
-184
+1.5
-170
+1.0
-128
+1.5
-175
+1.5
-186
+1.5
-186
+1.5
-186
+1.5
-186

NATIONALS
6-8
-1.5
+145
-1.5
+155
-1.5
+152
-1.5
+150
-1.0
+110
-1.5
+145
-1.5
+155
-1.5
+155
-1.5
+150
-1.5
+150


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