NFL Same Game Parlay Odds, Picks & Predictions: Week 18 (2025)

by Dan Servodidio |
Jan 04, 2025

We made it! NFL Week 18 is here, and itâ€™s time to lock in some best bets and props before the games kick off. The Sunday Week 18 slate is a loaded with playoff implications, divisional matchups, and tons of ways to go for props and picks. Letâ€™s dive into every game on the afternoon slate and find some winners.

Picking matchups against the spread (ATS) and betting on the over/under is more commonplace, but a same-game parlay (SGP) gives us even more added action. Letâ€™s find some plus-money SGP picks for every game on the NFL Week 18 Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing but are always subject to change up until kick-off. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Without further ado, letâ€™s dive into the best NFL Week 18 same-game parlays.

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Best NFL Same Game Parlay Bets (Week 18)

(Odds via DraftKings Sportsbook unless noted otherwise)

New York Giants at Philadelphia Eagles

Leg 1: Eagles Team Total Under 22.5 Points (-166)
Leg 2: Malik Nabers 70+ Receiving Yards (-135)
Leg 3: Tyrone Tracy Over 14.5 Receiving Yards (-120)

The Eagles will rest their starters this week with nothing to play for locked into the NFC No. 2 seed. The drop-off to the offensive backups is pretty notable. Philadelphia's offense is very top-heavy, especially at the skill positions. Plus, Tanner McKee may be in line to start at quarterback as Kenny Pickett is dealing with a rib injury.

We could see a ton of empty possessions from Philly's B-team offense - even against the weak Giants defense. Yes, McKee threw two touchdowns last week but they came in garbage time against a Dallas team that was already in quit mode. It might also be a conservative run-heavy game plan for the Eagles considering how bad New York is against the rush.

On the Giants side of things, their offense woke up last week with 45 points and 389 total yards against Indianapolis. The attack could have some success against the Eagles' backup defenders here. Let's grab a couple of New York player props as Brian Daboll's team looks ahead to next season.

Rookie Malik Nabers has been a lone bright spot for the Giants all year. He's especially been a favorite option for Drew Lock lately. In Lock's four starts, Nabers has 171, 68, 79, and 69 receiving yards while averaging 11.3 targets per game. Nabers is also averaging 88.8 yards per game over the past six with at least 64 yards in each. Though he had only 41 yards vs. Philadelphia earlier this year, he should have an easier time with the Eagles' starting corners resting.

Tyrone Tracy's rushing yards have been tough to predict, but his pass-catching role is a bit safer with Lock under center. In four Lock starts, Tracy has 33, 38, 43, and 14 receiving yards. He's doing just enough as a receiver lately to grab the over on his low line here. The Eagles have been strong defensively against pass-catching backs but, again, we're dealing with backups this week.

Parlay Odds: +440

Carolina Panthers at Atlanta Falcons

Leg 1: Over 48.5 Total Points (-105)
Leg 2: 1st Half Over 23.5 Points (-118)
Leg 3: Bijan Robinson 100+ Rushing + Receiving Yards (-235)
Leg 4: Drake London 70+ Receiving Yards (-110)

The Falcons are in a tough spot when it comes to their playoff hopes. They not only need to win at home against Carolina, but they also need Tampa Bay to lose. Considering the Bucs are sizable home favorites against the Saints, the postseason chances for Atlanta seem slim. Yet, those games will be happening at the same time - so the Falcons should be going full-throttle for the majority of this one.

With Michael Penix Jr. at quarterback, Atlanta's offense has put up 34 and 24 points in the past two games. The 34-point outing came at home against a poor Giants defense, which is a similar matchup as this one against Carolina's league-worst defense. Penix and the Falcons' attack should score plenty at home with the Panthers allowing 31.0 PPG this year.

The Atlanta defense is a bit too unpredictable to trust, though. Plus, the Panthers have been trending up over the past month or so with Bryce Young playing a lot better and more consistently. Carolina can score their fair share in this spot and force the Falcons to keep it up offensively. Grab the over for the full game and first half in a potential shootout.

Bijan Robinson gets a great matchup vs. Carolina here. The Panthers are allowing a league-high 143.6 rush yards per game to running backs and it's been profitable to back opposing RBs in this matchup almost every week. Robinson has 98 and 103 total yards in the past two games with Penix under center. The Falcons are leaning on their stud running back with a rookie at QB and that shouldn't change in a must-win game.

Drake London has led the Falcons in targets in both of Penix's starts so far. He just had seven catches for 106 yards on 13 targets last week. With Darnell Mooney questionable to play, London could be a big part of the offensive game plan and a top option for Penix this week. It helps that he faces a weak Panthers defense as well.

Parlay Odds: +460

Washington Commanders at Dallas Cowboys

Leg 1: Commanders -6.5 Spread (-108)
Leg 2: Commanders Team Total Over 26.5 Points (+110)
Leg 3: Commanders -3.5 1st Half Spread (-110)
Leg 4: Jayden Daniels 50+ Rushing Yards (+105)

Even with a playoff berth locked up, Washington should be motivated to win this week. The Commanders can clinch the No. 6 seed with a victory and avoid facing the Eagles in the first round. A potential matchup against either the Rams or Buccaneers is ideally a more favorable scenario than facing a division rival for the third time this season.

The Commanders are on a four-game winning streak coming into this game and are trending up at the right time. Meanwhile, Dallas came crashing back down to Earth last week in a 41-7 loss to Philadelphia. The Cowboys had been much more competitive in recent weeks but it's tough to quantify the motivation for a team that's firmly looking ahead to next year now. CeeDee Lamb's absence in the offense was glaring last week as the attack severely lacks reliable playmakers.

Washington head coach Dan Quinn has said publicly that they are playing this game hard despite just earning the playoff berth last week. The Commanders lost to Dallas in tough fashion in Week 12 and we should expect them to be out for revenge in this rematch. Jayden Daniels and Co. are averaging 30.8 PPG over the past five weeks and should keep it going against the weak Cowboys defense allowing 27.8 PPG this year (31st in NFL).

As long as the Commanders' starters are out there and playing to win, Daniels should be active as a runner. The rookie has run for 127, 81, and 66 yards in the past three games and he's averaging 76.4 rush yards per game over the past five contests. He had 74 rushing yards vs. Dallas last meeting and can exploit the defense once again. The Cowboys are allowing the third-most rush yards per game to opposing quarterbacks.

Parlay Odds: +415

Chicago Bears at Green Bay Packers

Leg 1: Packers -6.5 1st Half Spread (-115)
Leg 2: D.J. Moore Over 6.5 Receptions (+125)
Leg 3: Jordan Love Under 223.5 Passing Yards (-115)

The Packers should be motivated to start this game strong. With a win and a Commanders loss, Green Bay can move into the NFC No. 6 seed and avoid facing the Eagles in the first round of the playoffs. However, if Washington is leading big at halftime, we could see the Packers rest starters in the second half. That leaves the back door wide open for Chicago to make things interesting for the full-game spread.

So, let's just target the Packers to cover the first-half spread when we know they'll be going for it. The Bears are 0-7 ATS in the first half on the road this season. Caleb Williams has been slow early in road starts all season and the Green Bay defense should be buttoned up early on. The Packers are averaging 13.7 PPG in the first half this season (6th in NFL) while Chicago is scoring just 7.1 PPG over the first two quarters (31st).

Ever since the Bears switched offensive coordinators, D.J. Moore has been consistently racking up receptions on quick passes from Williams. Over the past seven games, Moore is averaging seven catches per contest with 6+ in each. He also has 7+ receptions in five of the past seven games. Moore had seven grabs against Green Bay in November and can replicate that this week.

As noted above, there's a decent chance the Packers rest starters in the second half if it looks like the Commanders will win as well. That scenario and the likely game script both point to Jordan Love's passing yards being limited. If Green Bay has an early lead as the spread indicates, the offense could be run-heavy in the second half as well.

Love also hasn't been throwing for a ton of yards recently. He's averaging just 200.5 passing yards per game over the past four weeks with fewer than 230 yards in five of the past six games. Plus, the Bears are allowing the fifth-fewest completions per game this year. Furthermore, cold and windy conditions in Green Bay on Sunday aren't exactly pass-friendly.

Parlay Odds: +650 (on BetMGM Sportsbook)

Houston Texans at Tennessee Titans

Leg 1: Texans +0.5 1st Half Spread (-130)
Leg 2: Under 42.5 Total Points (-245)
Leg 3: Tony Pollard Anytime Touchdown (-145)

The Texans are locked into the AFC No. 4 seed and thus have nothing to play for this week. That fact would explain why the Titans are slight home favorites. Yet, Houston head coach Demeco Ryans said that he'll still play the starters. How long they're out there - especially C.J. Stroud, Nico Collins, and other main offensive starters - is another question.

The full-game spread is off the table because there's a good chance the Texans rest some key players in the second half. However, it would be smart for the Houston offense to go full throttle early on to establish some rhythm ahead of next week's playoff matchup. The Texans mustered only two points against the Ravens last game and have looked a bit lifeless since Tank Dell's season-ending injury vs. Kansas City.

Houston boasts a 12-4 ATS record in the first half, tied for best in the league with Detroit. Stroud and the offense should be motivated to put together a few scoring drives early and establish confidence heading into the postseason. There's clear value on the Texans to lead at halftime if they take things seriously for a quarter or two at least.

At the same time, the Texans could rest some of those key starters in the second half. That means Davis Mills at quarterback and likely a run-heavy game plan to avoid injuries. On the other side, Tennessee is expected to give both Will Levis and Mason Rudolph snaps. The offense has struggled with both under center and should keep things lower-scoring overall. Grab the alt under of 42.5 total points.

Even so, Tony Pollard's contract incentives are hard to ignore this weekend. He needs 83 more rushing yards for a $250,000 bonus and two touchdowns for another $200,000. The murky part of this is that Pollard sat out last week and has been limited in practice. Keep an eye on his status. For now, let's grab his anytime touchdown odds with the yards not available as of this writing.

Parlay Odds: +400 (on ESPN Bet)

Jacksonville Jaguars at Indianapolis Colts

Leg 1: Over 43.5 Total Points (-115)
Leg 2: Brian Thomas Jr. 70+ Receiving Yards (-180)
Leg 3: Josh Downs 50+ Receiving Yards (-125)
Leg 4: Joe Flacco 225+ Passing Yards (-180)

The Jaguars and Colts are both playing for pride in this divisional game. On the surface, this AFC South showdown should be lower-scoring with a quarterback matchup of Mac Jones vs. Joe Flacco. However, the over is firmly in play as we could see a mini-shootout.

Joe Flacco will start for Indianapolis again with Anthony Richardson ruled out. The Colts offense is much more of a passing threat downfield with Flacco under center. They put up 33 points against the Giants last week as Flacco threw for 330 yards. Meanwhile, the Indy defense got exposed by New York a week ago with 45 points and 389 total yards allowed.

These teams played to a 37-34 final back in Week 5. Flacco started that game and threw for 359 yards and three touchdowns. He took full advantage of Jacksonville's league-worst pass defense. As for the Jags, the offense has had success against subpar defenses this year and Indy is a bottom-10 unit against the pass. Mac Jones has been playing a bit better than you'd think lately and can do just enough to help the over-cash.

Speaking of Jones, he loves throwing to standout rookie Brian Thomas Jr. In the past six games with Jones at quarterback, Thomas is averaging 95.3 receiving yards per game with at least 76 in each and 80+ in five of six. Thomas went off for 122 yards against the Colts earlier this season too. He should get to 70+ yards easily with double-digit targets in five straight games now.

On the Colts' side of things, Flacco should be looking at Josh Downs plenty. He only had 22 yards on three catches last week but was previously a favorite target for Flacco. In the veteran quarterback's four previous starts, Downs had 60+ yards and 6+ receptions in all four games. Downs had nine catches for 69 yards vs. Jacksonville earlier this season with Flacco under center too.

Parlay Odds: +470

Buffalo Bills at New England Patriots

Leg 1: Under 36.5 Total Points (-112)
Leg 2: 1st Half Under 17.5 Points (-110)
Leg 3: Bills Team Total Under 20.5 Points (-130)
Leg 4: Patriots Team Total Under 17.5 Points (-142)
Leg 5: Bills Moneyline (-155)

This may be the toughest Week 18 game to handicap. The Bills are locked into the AFC No. 2 seed and have nothing to play for. We know Josh Allen will start and play a handful of snaps to keep his consecutive games streak going, but he'll give way to Mitch Trubisky early. Buffalo is expected to rest many other starters as well with a playoff game coming up next week.

Meanwhile, the Patriots are on a six-game losing streak and just got blown out at home by the Chargers, 40-7. Drake Maye is dealing with an injury to his throwing hand but is still likely to start this week. Even if he does start, we could see Jacoby Brissett and Joe Milton get some run in the second half. With a loss, New England can lock up the No. 1 pick in the 2025 NFL Draft.

That situation makes things interesting if it's a close game in the fourth quarter. So, do we trust Mitch Trubisky and the backup Bills or a tanking Patriots team with a banged-up rookie quarterback? Plus, it's expected to be cold and windy in Foxborough on Sunday for this divisional clash.

Considering all of the factors, offense may be at a premium here. Let's root for a low-scoring game as we grab the under for the first half and full game. Add in the unders for both team totals as well. The final scoreline could easily be 17-13 or around that with a late score or two.

Finally, we should have more confidence overall in the Bills to win this game. The Patriots got a gift from the Giants' victory last week and are in prime position to pick first in the NFL Draft with a loss this weekend. Of course they won't be trying to lose (wink, wink) - but don't be surprised if Maye and other starters hit the bench late. Jerod Mayo is likely back as head coach so it's not like they'll be trying to win one more for him either. Buffalo also just has that winning mindset right now even if it's Trubisky and the backups.

Parlay Odds: +420

New Orleans Saints at Tampa Bay Buccaneers

Leg 1: Buccaneers Team Total Over 27.5 Points (-130)
Leg 2: Mike Evans 90+ Receiving Yards (-180)
Leg 3: Baker Mayfield 250+ Passing Yards (-115)
Leg 4: Bucky Irving 80+ Rushing Yards (-195)

Tampa Bay's playoff scenario is a simple one this weekend. If the Buccaneers beat the Saints at home, they clinch the NFC South title and host a playoff game next week. New Orleans has nothing to play for and the offense likely struggles again with Derek Carr ruled out and Alvin Kamara doubtful.

The double-digit spread is a bit too large to back the Bucs in this spot, though. Let's just target their team total to play it safe. Tampa should find little resistance against a Saints defense that allowed 25 points to the Raiders last week and 34 points to the Packers two games ago. The Buccaneers put up 51 against New Orleans earlier this season and are averaging 32.7 PPG over the past six games.

You may have heard about the Mike Evans situation. The veteran wideout needs 85 receiving yards to get to 1,000 for the 11th straight season. The sportsbooks have reacted accordingly by pricing up his yardage prop. Even so, bank on the Baker Mayfield and the Bucs making sure their guy gets there. We saw it last week when Evans had 97 yards on eight catches.

As for Mayfield, he should get to 250 passing yards with several contract incentives in play - besides the Bucs needing to win to make the playoffs. Mayfield can earn up $2.5 million if he finishes top 10 in the NFL or top 5 in the NFC in multiple major passing categories. He's currently set to earn all of them but a good passing day would ensure that. Mayfield has 250+ yards in five of the past six games and eight of the last 11 contests.

How about one more Bucs prop to finish things off? Bucky Irving is averaging 101.8 rushing yards over the past six games when he's seen double-digit carries. He has 100+ rush yards in three of the last five games as well. With Tampa gearing up for the playoffs, expect Irving to continue getting the majority of work over Rachaad White. This is a great matchup with the Saints allowing the third-most rush yards per game in the league.

Parlay Odds: +440

Kansas City Chiefs at Denver Broncos

Leg 1: Broncos Team Total Over 23.5 Points (-148)
Leg 2: Marvin Mims Over 33.5 Receiving Yards (-120)
Leg 3: Marvin Mims Over 2.5 Receptions (-190)
Leg 3: Jaleel McLaughlin Over 36.5 Rushing Yards (-115)

The Chiefs are locked into the AFC No. 1 seed and have nothing to play for this weekend. Kansas City will rest its starters with Carson Wentz getting the nod at quarterback. Meanwhile, the Broncos control their own destiny and can clinch a playoff berth with a win. Considering both situations, Denver is unsurprisingly a double-digit favorite at home here.

It's very tempting to back Andy Reid and the Chiefs to cover the large spread as it seems like a market overreaction. At the same time, the Broncos are 7-0 ATS as favorites this season and 5-2 ATS at home. Instead, let's target the Denver team total.

Whether they cover the spread or not, the Broncos should have success offensively against Kansas City's backup defenders - especially with Chris Jones out. Let's just focus on the Denver offense with this parlay. The Broncos are averaging 31.3 PPG in their past six home games with at least 28 in five of those. In a must-win scenario, expect Sean Payton to have a good game plan for Bo Nix and the offense to put up points - especially if Wentz and the Chiefs make things interesting.

You may have heard about Courtland Sutton's contract incentive this week, but we're targeting a different Denver receiver. Marvin Mims has been a bigger part of the offense over the past two months. He's averaging 63.8 receiving yards per game over the past six contests with at least 44 in five of six. Mims also has 3+ catches in five straight and six of the past seven.

Another under-the-radar Broncos offensive player worth including in parlays is Jaleel McLaughlin. The second-year back appears to be the team's best rushing option right now heading into the playoffs. McLaughlin had 10 carries for 69 yards last week when Javonte Williams saw zero carries. Three games ago, McLaughlin had 14 carries for 84 yards when Williams had just four attempts for one yard. He's averaging 4.7 yards per carry this season and has 40+ rushing yards in five of seven games when seeing 7+ carries.

Parlay Odds: +410

Los Angeles Chargers at Las Vegas Raiders

Leg 1: Brock Bowers Over 7.5 Receptions (-110)
Leg 2: Brock Bowers 70+ Receiving Yards (-140)
Leg 3: Aidan O'Connell 225+ Passing Yards (-120)
Leg 4: Jakobi Meyers 70+ Receiving Yards (-105)

Before discussing any picks or props from this game, let's review some playoff scenarios. If the Steelers beat the Bengals on Saturday, then the Chargers will be locked into the No. 5 seed and have nothing to play for. In that case, Los Angeles may choose to rest Justin Herbert and other key starters. If the Bengals win, then the Chargers will be motivated to win as well to secure that fifth seed. Unfortunately, we won't know any of this until the Steelers-Bengals game concludes on Saturday night.

So, the wait-and-see approach may be the best way to attack this game from a betting standpoint. However, we can still target some Raiders props for players that we know will be out there. Though Las Vegas has been eliminated from the playoffs for weeks now, the offense is still competing.

It begins and ends with stud rookie tight end Brock Bowers. The Raiders should be motivated to feed Bowers in this regular-season finale with a couple of records up for grabs. Bowers has 108 receptions on the year, which is the current rookie record, but Malik Nabers isn't far behind at 104. Plus, Bowers is just eight catches behind Zach Ertz for the single-season reception record for tight ends (116). He has 8+ receptions in seven games already and should see a healthy amount of targets here.

Jakobi Meyers can also be productive while Bowers racks up receptions. The Vegas passing attack is basically a two-man game with Meyers and Bowers dominating the target share. Meyers is averaging 64.6 receiving yards per game this season and 66.5 per game with Aidan O'Connell at quarterback.

If Bowers and Meyers are having good games, then O'Connell should naturally have a decent yardage day himself. He's averaging 266.5 passing yards per game in his four full games this season with at least 225 in each. He also has at least 35 pass attempts in each game. The Raiders are letting him throw it around and there should be enough volume to hit 225 this week once again.

Parlay Odds: +410

Seattle Seahawks at Los Angeles Rams

Leg 1: Seahawks -6.5 Spread (-122)
Leg 2: Geno Smith 200+ Passing Yards (-450)
Leg 3: DK Metcalf 60+ Receiving Yards (-150)
Leg 4: Jaxon Smith-Njigba 60+ Receiving Yards (-130)

With the NFC West locked up and nothing else to play for seeding-wise, the Rams will rest Matthew Stafford and other starters this week. That means Jimmy Garappolo at quarterback and a significant drop-off to the backup skill position players. We saw how shaky the Los Angeles offense was when Cooper Kupp and Puka Nacua were out earlier this season.

Meanwhile, the Seahawks will be treating this like a normal regular-season game despite being eliminated from playoff contention. Getting to 10 wins in Mike McDonald's first season as head coach would be a notable accomplishment and this veteran-laden Seattle team should win easily over the Rams' reserves. The betting market has reacted accordingly with the spread flipping from the Rams -2 to the Seahawks as touchdown road favorites.

If you haven't heard, Geno Smith can earn a ton in contract incentives this week. He'll make $2 million each for besting his career highs in passing yards, completion percentage, and season win total. That means 184 more passing yards, maintaining his current 70.2% completion rate, and leading Seattle to a win en route to earning $6 million. Let's play it safe with the low bar of 200+ passing yards because he only needs 184 to hit the incentive.

As Smith tries to avoid incompletions and throw for enough yards, he should be looking at DK Metcalf and Jaxon Smith-Njigba plenty. Metcalf is also 61 receiving yards away from hitting 1,000 for the season. It's a number he's hit in back-to-back seasons and he should be motivated to get there again - especially if Smith does his receiver a favor.

As for JSN, the 60+ yard mark is low for what he's been doing. The second-year receiver was held to just 32 yards last week but had at least 69 yards in the previous eight games - averaging 96.3 per contest in that span. Smith-Njigba tore up the Rams earlier this season with 180 yards on seven catches and 13 targets. Even with Metcalf getting his, JSN can do damage too.

Parlay Odds: +425

Miami Dolphins at New York Jets

Leg 1: Jets Moneyline (-102)
Leg 2: Davante Adams Over 5.5 Receptions (-135)
Leg 3: Tyler Huntley 25+ Rushing Yards (-180)

The Dolphins are still alive for an AFC Wild Card spot but need help this weekend. They have to win but also need Denver to lose. Considering the Broncos are double-digit favorites at home against Kansas City's backups, Miami appears likely to finish outside of the playoff picture. It doesn't help that Tyler Huntley is trending towards starting at quarterback amid Tua Tagovailoa's hip injury.

Meanwhile, the Jets will wrap up their disappointing season with this home game. Backing this team in the betting markets has been unwise all year - but we'll try to do it one more time. There's a real possibility this is Aaron Rodgers' last game of his career, as he's talked about publicly this week. The Jets, especially the veterans, may be more motivated than normal to send him out a winner.

This is also a revenge spot for the Jets. They lost to the Dolphins in overtime on the road earlier this year and now have a chance to end their division rivals' season. We also have to consider the cold and wintry conditions expected in New York for this one. That will slow down Miami's explosive playmakers and keep things lower-scoring - providing more value for the Jets to pull out the victory.

If this is indeed Rodgers' last game, expect him to target Davante Adams plenty. The two longtime teammates and friends should be motivated to end the season strong. Adams has at least five catches in eight straight games with 6+ in six of those. He's averaging 6.8 receptions over the past eight games as well. Adams had only five catches last week but should go over that as he caught seven, nine, and nine passes in the three prior games. He went for nine grabs on 11 targets vs. Miami in the first meeting.

As noted, Tyler Huntley is expected to start for Miami. The passing is risky to count on with Huntley but the dual-threat quarterback is known to use his legs. Huntley is averaging 29.8 rush yards per game in his four starts this season and just had 52 yards last game. He's also averaging 38.7 per contest in his career when starting or playing the majority of QB snaps in games.

Parlay Odds: +500

San Francisco 49ers at Arizona Cardinals

Leg 1: Cardinals -4.5 Spread (-110)
Leg 2: Kyler Murray Over 33.5 Rushing Yards (-125)
Leg 3: Michael Carter Anytime Touchdown (+125)

This NFC West matchup is one of the few Week 18 games featuring teams who are both already eliminated from playoff contention. We also have a pair of squads stuck in losing skids recently. The Cardinals are 1-5 over the past six games as they collapsed late. The 49ers are 1-6 over the past seven and have lost three straight.

The situations for both teams are pretty ugly right now but we should have more confidence in Arizona at home. The 49ers will start Josh Dobbs at quarterback with Brock Purdy injured. Despite Dobbs' scrambling ability, this downgrades an offense that's been struggling lately anyway. We also have to wonder about San Fran's motivation at this point in a lost season for the reigning NFC champs.

Arizona put up just nine points against the Rams last week but still gained 396 total yards of offense. We should see Kyler Murray and the attack have success against a 49ers defense that's allowing 28 PPG on the road this year. San Francisco is also 0-3 ATS as underdogs this season and 0-5 ATS as dogs over the past three years combined. Meanwhile, the Cardinals are 4-1 ATS in their last five home games.

Murray is still one of the best running quarterbacks in the league and his rushing yards line looks like a bargain this week. His 550 rush yards this season are the most he's had since 2020, averaging a career-high 7.3 yards per carry. Murray is running for 34.4 yards per game and he has 30+ in half of the games this year. Notably, Murray has run for 83, 49, 75, and 91 yards in four of his last five matchups vs. San Francisco.

Michael Carter is in line to be the Cardinals' lead back with James Conner placed on IR. Carter stepped up with 81 total yards on 15 touches last week after Conner got hurt. He didn't score but has a great shot at doing so at home here. The 49ers have allowed 22 rushing touchdowns this season, the second-most in the league.

Parlay Odds: +435

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