NFL Week 1 Odds, Picks & Predictions: Browns vs. Panthers (2022)

Here is our preview and best bet for the 2022 NFL Week 1 game between the Browns vs. Panthers.

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NFL Week 1 Odds, Picks & Predictions: Browns vs. Panthers

The Carolina Panthers’ acquisition of former Cleveland Browns starting QB Baker Mayfield provides this contest with a degree of intrigue it would otherwise be lacking. Mayfield's recent comments only add intrigue to the matchup, and this contest has quickly become one of the most compelling of the Week 1 slate.

Cleveland should have success rushing against the Panthers' defensive front, but expect backup QB Jacoby Brissett to struggle to keep pace with a revamped Carolina offense helmed by a vengeful Baker Mayfield. The Browns have gone winless in season openers since 2004, and it is unlikely that they will buck that trend in 2022.

Picks: Panthers -2. Lean u42


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