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NFL Week 1 Odds, Picks & Predictions: Chiefs vs. Cardinals (2022)

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Here is our preview and best bet for the 2022 NFL Week 1 game between the Chiefs vs. Cardinals.

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NFL Week 1 Odds, Picks & Predictions: Chiefs vs. Cardinals

Two of the League's best offenses meet in the desert as the Kansas City Chiefs travel to face the Arizona Cardinals. The Cards were excellent in 2021, and have tended to start strong since HC Kliff Kingsbury’s arrival in 2020. However, Arizona has undergone a tumultuous offseason highlighted by off-field distractions, and the Chiefs are far from the ideal opponent to begin the season.

The Cardinals were substantially better as the road team in 2021, and they will surely miss WR DeAndre Hopkins' production in attempting to keep pace with the KC offense. Even still, this line has ballooned to Chiefs -6 since opening as KC -3 early in the offseason, and it is hard to push strongly for a KC bet at this point, knowing that much of the value has been priced out.

Picks: Lean Chiefs -5.5, Lean u54


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