NFL Week 1 Same Game Parlays Odds, Picks & Predictions (2022)

Finally, Week 1 of the NFL season is here. And betting parlays are one of the most exciting ways to get involved in the action. Each week, I’ll go through each game and give you my favorite same-game parlay picks, as well as my favorite parlay involving sides and totals.

Let’s roll right into my Week 1 parlay picks.

All odds courtesy of DraftKings Sportsbook 

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

Week 1 Parlay

• Leg 1: Under 40.5 in 49ers-Bears
• Leg 2: Houston Texans +7.5
• Leg 3: Pittsburgh Steelers +6.5

Odds: +530 ($100 to win $530)

The 49ers could be without George Kittle, making matters even harder for Trey Lance. Chicago has done a terrible job of surrounding Justin Fields with talent and protection. Plus, rain and high winds are expected. The Colts have lost their season opener every year under Frank Reich, and Week 1 divisional dogs are highly profitable. Pittsburgh’s offense has question marks, but the defense remains elite. Plus, Mike Tomlin is an excellent dog to back, as he’s 32-22-1 as a road underdog since 2007.

San Francisco 49ers -7 at Chicago Bears, Total 40.5

• Leg 1: Under 40.5
• Leg 2: Elijah Mitchell over 64.5 rushing yards
• Leg 3: Darnell Mooney over 4 receptions

Odds: +450

I’m expecting low scoring in this Bears-49ers game. However, Mitchell should be the clear lead back now as he hasn’t appeared on the injury report this week after nursing a hamstring injury throughout camp. Mitchell went over this total eight times last year, and our BettingPros projections project Mitchell to have 71.5 rushing yards, showing big value on the over. And while I’m not a believer in the Bears’ offense, I do expect Justin Fields to feed Darnell Mooney, who caught at least four balls in all but five games last year.

Indianapolis Colts -7.5 at Houston Texans, Total 45.5

• Leg 1: Davis Mills over 219.5 passing yards
• Leg 2: Parris Campbell over 24.5 receiving yards
• Leg 3: Texans +7.5

Odds: +475

The Colts have stumbled out of the gates during Frank Reich’s tenure, and Mills could put up a good day against a Colts secondary that’s really inexperienced beyond Stephon Gilmore and could play a ton of Cover 3 under new defensive coordinator Gus Bradley. When Campbell’s been healthy, he’s been productive and could be the big play threat in Indy’s offense.

Baltimore Ravens -6.5 at New York Jets, Total 44.5

Many of Baltimore’s props were off the board as of writing, as the team has yet to provide clarification on whether J.K. Dobbins will play. While we can’t get odds just yet, here are the legs I’d be targeting. 

• Leg 1: Mike Davis over rushing yards
• Leg 2: Mark Andrews over receiving yards
• Leg 3: Elijah Moore over receiving yards

I anticipate Davis to get the majority of the work between the tackles even if Dobbins is active. The Jets were one of the most generous teams to opposing tight ends a year ago. And Moore caught fire at the end of the year with Joe Flacco under center and could be in store for a big day.

Pittsburgh Steelers at Cincinnati Bengals -6.5, Total 44 

• Leg 1: Najee Harris under 29.5 receiving yards
• Leg 2: Steelers +6.5
• Leg 3: Joe Burrow under 254.5 passing yards

Odds: +450

Harris benefitted from Ben Roethlisberger checking the ball down often to avoid sacks. With a new QB under center, I’d expect Harris to see less work in the passing game. Pittsburgh’s defense is still one of the league’s best and held Burrow to fewer than 200 passing yards in both contests last year.

Cleveland Browns at Carolina Panthers -1.5, Total 42.5 

• Leg 1: Under 42.5 points
• Leg 2: Donovan Peoples-Jones over 29.5 receiving yards

Odds: +340

This is admittedly one of my least favorite games on the board. However, I do expect a low-scoring affair. Baker Mayfield could struggle against his former team, as Cleveland still boasts one of the league’s best defenses. Carolina will load the box and dare Jacoby Brissett to beat them. Peoples-Jones is flying under the radar but should be the No. 2 option in the passing game behind Amari Cooper. He has big play ability, too, posting seven catches of 20+ yards a year ago. One grab could be all he needs to clear this total.

New Orleans Saints -5.5 at Atlanta Falcons, Total 42.5 

• Leg 1: Cordarrelle Patterson over 29.5 rushing yards
• Leg 2: Falcons +5.5

Odds: +170

This is another game I don’t love. I’m sticking with the theme of betting home divisional dogs. And while there’s speculation about Atlanta’s run game, I still think Patterson will get the most usage.

Philadelphia Eagles -3.5 at Detroit Lions, Total 48.5

• Leg 1: Amon-Ra St. Brown under 54.5 receiving yards
• Leg 2: Jalen Hurts under 249.5 passing yards
• Leg 3: D’Andre Swift under 54.5 rushing yards

Odds: +475

Hurts eclipsed 250 passing yards just four times last season and could be abandoning the pocket more often against Aidan Hutchinson and Detroit’s improved pass rush. St. Brown was the beneficiary of Detroit getting down big early, prompting opposing defenses to yield shorter chunks in the passing game. I’m fading St. Brown in Week 1 in what should be a closer game script. As for Swift, he only topped 55 rushing yards in two games last season. And if I learned anything from Hard Knocks, it’s that this coaching staff loves veteran Jamaal Williams. This may not be a timeshare, but Williams will factor in.

Jacksonville Jaguars at Washington Commanders -2.5, Total 43.5

• Leg 1: Trevor Lawrence over 249.5 passing yards
• Leg 2: Antonio Gibson over 59.5 rushing yards

Odds: +390

A new coach and a new year could bring big things for Trevor Lawrence, and I’m backing him against a Commanders defense that ranked 28th in pass defense DVOA a year ago and won’t have Chase Young healthy. There was no prop on Kirk as of writing, but I think he’ll be Lawrence’s top option because of his knack for finding holes in zone coverage. The Gibson play may come off as contrarian given the tumultuous offseason he had. But with Brian Robinson sadly sidelined, Gibson will be the guy for now. And he faces a Jaguars defense that ranked 19th in run defense DVOA a year ago.

New England Patriots at Miami Dolphins -3.5, Total 46.5 

• Leg 1: Over 46.5
• Leg 2: Mac Jones over 219.5 passing yards
• Leg 3: Tyreek Hill over 69.5 receiving yards

Odds: +360

There are some misperceptions about both of these defenses. The Patriots lost cornerback J.C. Jackson to free agency and have significant questions on the back end of the defense. Miami loses mastermind Brian Flores and benefitted a ton from a favorable schedule against backup quarterbacks. That could yield to a higher-scoring game than anticipated, especially if you believe in a year two bump for Mac Jones. As for Hill, I expect him to do more work horizontally in an offense that’ll mimic how San Francisco schemed Deebo Samuel open.

Green Bay Packers -1.5 at Minnesota Vikings, Total 47.5

Note: No Packers receiving props were listed as we await news on Allen Lazard’s status. Romeo Doubs’ over in receiving yards would be a recommendation. 

• Leg 1: Dalvin Cook under 74.5 rushing yards
• Leg 2: Aaron Jones over 54.5 rushing yards
• Leg 3: AJ Dillon anytime TD scorer

Odds: +600

Cook has failed to top 75 rushing yards in four of his seven games against Green Bay. The arrival of Kevin O’Connell in Minnesota could mean more aggressive play calling and fewer rush attempts. Plus, Green Bay has one of the best front-sevens in the league. On the flip side, I expect both Jones and Dillon to get a lot of work against a Vikings defense that ranked 25th in run defense DVOA a season ago. Dillon scored seven total touchdowns a year ago and should get any cracks at the goal line.

New York Giants at Tennessee Titans -5.5, Total 43.5

• Leg 1: Robert Woods over 54.5 receiving yards
• Leg 2: Giants +5.5
• Leg 3: Derrick Henry over 104.5 rushing yards

Odds: +850

Robert Woods is fully healthy after his ACL tear last year, and he’s the only show in town thanks to Treylon Burks’ early struggles. I’d expect him to be the focal point of the passing game. As for Henry, he’s going against a Giants front seven that ranked dead-last in rush defense DVOA. And if Tennessee is leading late in the second half, you know he’ll be getting the ball. Finally, while I like both of these Tennessee player props going over, I do expect the Giants to keep this game close. New head coach Brian Daboll should bring instant credibility to this offense, and he’s got some playmakers to work with on both sides of the ball.

Las Vegas Raiders at Los Angeles Chargers -3.5, Total 52.5 

• Leg 1: Josh Jacobs anytime TD scorer
• Leg 2: Hunter Renfrow under 44.5 receiving yards
• Leg 3: Justin Herbert over 279.5 passing yards

Odds: +600 

After an offseason filled with speculation over Jacobs’ role within the Vegas offense, I’m taking him to get in the end zone. He’s still the lead back and should get the goal line work against a Chargers defense that was terrible against the run a year ago. Renfrow posted 45 and 13 receiving yards in two games against the Chargers a year ago. And Herbert could carve up a Raiders secondary that ranked 21st in pass defense DVOA a year ago and still has significant questions.

Kansas City Chiefs -5.5 at Arizona Cardinals, Total 53.5

• Leg 1: JuJu Smith-Schuster over 49.5 receiving yards
• Leg 2: James Conner 54.5 rushing yards
• Leg 3: Over 53.5

Odds: +525

I believe Smith-Schuster emerges as Kansas City’s top receiving option not named Travis Kelce. The Chiefs ranked 20th in run defense DVOA a year ago, and our projections have Conner’s rushing total at 62.2 yards for Week 1. I think we’ll see fireworks between these two offenses in a back-and-forth affair.

Tampa Bay Buccaneers -2.5 at Dallas Cowboys, Total 50.5

• Leg 1: Under 51
• Leg 2: Ezekiel Elliott under 49.5 rushing yards
• Leg 3: Tom Brady under 279.5 passing yards

Odds: +360

Both offenses come into this game with glaring issues along the offensive line. And I expect this game to be more of a defensive showing than anticipated. In last year’s season opener, we saw the Cowboys attack Tampa Bay’s secondary, leaving Zeke with just 33 rushing yards on 11 carries. I expect to see a similar game plan Sunday against Tampa’s dominant front. As for Brady, I’m a bit concerned about the off-season distractions. Plus, Tampa is replacing three starters on the interior of the offensive line. That could spell trouble for the GOAT.

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