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NFL Week 1 Thursday Night Football Odds, Picks & Predictions: Bills vs. Rams (2022)

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Here is our preview and best bet for the 2022 NFL Week 1 game between the Bills vs. Rams.

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NFL Week 1 Odds, Picks & Predictions: Bills vs. Rams

Buffalo is coming into the season as Super Bowl favorites and has the MVP favorite in Josh Allen. Von Miller will also be making his debut against his former team in the same place he won a championship with them. Jordan Poyer has returned to practice and should be able to play, but Tre'Davious White will not play. That should be a problem against one of the league's best passing offenses which averaged 11.4 yards per completion last season.

The Rams will look to throw the ball and take advantage of their superior matchups outside. Cooper Kupp and Allen Robinson should be able to get open. The Rams also add Bobby Wagner to their already stellar defense, which allowed four rushing yards per attempt. This will be a close matchup but expect the Rams' defense to make a game-changing play for their home crowd.

Picks: Rams +2.5 | Lean o52.5


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