NFL Week 10 Odds, Picks & Predictions: Vikings vs Bills (2022)

Let’s take a look at our favorite odds, picks, and predictions for the Week 10 NFL game Vikings vs Bills.

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(Odds via FanDuel Sportsbook)

NFL Week 10 Odds, Picks & Predictions: Vikings vs Bills

Josh Allen was injured in the Bills' loss to the Jets last week and is day-to-day with an elbow injury. Case Keenum will step in against his former team if he misses this week. It is a good matchup for either quarterback since the Vikings allow 10.9 yards per completion. Whichever quarterback plays, he has a matchup that will produce open targets, but there will be less production with Keenum.

The Vikings have been balanced on offense this season, while the Bills have been one of the best defensive units. The area of concern for Buffalo is their run defense, as they have allowed 150 rushing yards per game in their last three games. Matt Milano was limited Wednesday and will help if he plays. The Vikings ran for 56 yards last week but had 173 against the Cardinals the week prior, so they are a threat.

Lean Bills -3.5, o43.5

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