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NFL Week 12 Odds, Picks & Predictions: Saints vs 49ers (2022)

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Thanksgiving is in the rearview, but there is still plenty of NFL action for Week 12. Let’s take a look at our preview and best bet for the NFL Week 12 game Saints vs 49ers.

And check out our predictions for other Week 12 NFL games:

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NFL Week 12 Odds, Picks & Predictions: Saints vs 49ers

The 49ers obliterated the Cardinals on Monday night and will have one less day to prepare for this game. Their elite defense has only allowed the least amount of yardage this season. Andy Dalton performed well last week against the Rams, with only four incompletions and three TDs, but may face a challenge this week.

The Saints struggle versus the run and allow the most rushing yards per game in the last three games. They have given up 184.3 yards in that span. San Francisco has averaged 142.3 rushing yards per game during that span, and Christian McCaffrey is to blame for that. The 49ers have playmakers galore, and all can run with the ball. Deebo Samuel is dealing with a hamstring injury, and his health is worth monitoring until game time. Christian McCaffrey and George Kittle are capable of shouldering the load if Deebo does not play.

Lean 49ers -8.5, o42.5

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