NFL Week 12 Pick’em Pool Predictions (2024)

Five of the 13 Week 12 NFL games have point spreads of seven points or more. While that means we're in for some mismatches, there are also quite a few games that feel like coin flips, especially in the late window and primetime.

Below, I take a look at four of the closest games of the week and predict who will win each contest.

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NFL Week 12 Pick’em Pool Predictions

San Francisco 49ers vs. Green Bay Packers

After Sunday's loss to the Seattle Seahawks, the 49ers have now lost three games in which they've led in the fourth quarter. In two of those games, they held leads of at least 10 points in the final 15 minutes of the game. All of this is to say, that the 49ers were very close to being 7-3 entering this matchup, they just need to find a way to close games.

They don't get an easy matchup on Sunday, as they have to travel to Green Bay to take on the 7-3 Packers. However, there is one major reason why I like the 49ers in this game. Turnovers.

While the 49ers have played sloppy football at times this season, the defense is forcing 1.1 interceptions per game, tied for fifth-most in the league. That's terrible news for Jordan Love, a quarterback who has thrown at least one interception in every game this season.

Brock Purdy has eight interceptions this season, but he's thrown just one over the last three weeks. He also has four touchdown passes during that stretch. The Packers' defense struggled last week against the Chicago Bears, allowing 391 yards and forcing zero turnovers. I expect them to look even worse this week. 

Pick: 49ers


Arizona Cardinals vs. Seattle Seahawks

The Cardinals and the Seahawks will meet twice over the next three weeks for massive NFC West contests. This is the tightest point spread of the weekend, with the Seahawks favored by just one point.

Geno Smith is currently fourth in the league in passing yards. He's posted 2,781 thus far, but he has just 11 touchdowns this season. That's the same amount of interceptions he has through 10 games. Yet, even with his turnover troubles, he should be able to move the ball with relative ease against the Cardinals' 21st-ranked pass defense. 

The Cardinals will need to counter Smith with a healthy dose of James Conner, as the Seahawks are allowing 138.6 rushing yards per game, the sixth-most in the league.

Kyler Murray has also made a lot happen with his legs this season. If he gets going, it could be a long day for the Seahawks' defense. But with all that said, this is still a coin flip. When that's the case, I almost always back the home team.

Pick: Seahawks


Philadelphia Eagles vs. Los Angeles Rams

The Eagles are one the hottest teams in football right now, winning six consecutive games with three of those wins coming by 20 or more points. They picked up a massive win over the Washington Commanders last Thursday. They currently look like the only team in the NFC that can steal the top seed away from the Detroit Lions.

But the Rams are no pushover. They've won four of their last five games. With their offense entirely healthy, they've scored at least 26 points in three of their last four games.

Matthew Stafford has thrown for over 290 yards in three consecutive games. Though he's facing the Eagles' second-ranked pass defense, it's hard to imagine him, Puka Nacua and Cooper Kupp being completely shut down.

This is a letdown spot for the Eagles, as they come off a huge win that puts them in the driver's seat for the NFC East. With a meeting with the Baltimore Ravens on the horizon, they may be looking past the Rams. And since the Rams play in the NFC West, they can't afford any letdown games. Give me the Rams in a tight contest.

Pick: Rams


Baltimore Ravens vs. Los Angeles Chargers

Monday Night Football features a massive game between two teams that are vying for AFC Wild Card positions. The Chargers have won four games in a row. They managed to defeat the Cincinnati Bengals last week despite allowing a season-high 27 points. Meanwhile, the Ravens have lost two of their last four, and the offense was held to just 16 points last week.

This game is a matchup between two teams that play very different styles. The Ravens are averaging over 30 points per game, while the Chargers are allowing just 14.5 points per contest, the fewest in the NFL this season. 

While this game could go either way, the Chargers are playing better football right now. Plus, one major advantage they have entering this week is they just played a team very similar to the Ravens.

The Bengals are a team with a great offense and a weak defense, which has been the exact story for the Ravens this season. If there were any questions about the Chargers’ offense, they were answered last week.

Pick: Chargers


Make sure to check out our other best bets for Tuesday:

Phil Wood is a featured writer at BettingPros. For more from Phil, check out his archive and follow him @Phil_Wood_Jr.

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