NFL Week 18 Moneyline Parlay Odds, Picks & Predictions (2025)
There are so many awkward lines in Week 18. Many teams are either chasing playoff spots, chasing a better overall pick or sitting starters after clinching a playoff berth already.
It can be challenging to navigate all of this. However, I’ve done the hard part and added a couple of parlays to consider for Week 18 in the NFL.
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NFL Week 18 Best Moneyline Parlays
(Odds courtesy of DraftKings Sportsbook)
Moneyline Parlay #1
- Leg 1: Cincinnati Bengals Moneyline (-130)
- Leg 2: Philadelphia Eagles Moneyline (-142)
- Leg 3: Buffalo Bills Moneyline (-135)
With a win on Saturday, the Cincinnati Bengals can still make the playoffs. They’ll need help from other teams, but ultimately, Cincinnati will be at full strength and will put their best foot forward on the road against Pittsburgh. Recently, the Steelers have struggled and looked a bit disconnected. Look for the Bengals to take advantage.
Meanwhile, the Eagles will rest most of their starters. But even after a win against the Colts, does anyone have faith that the Giants will pull out another win before the season concludes? They got everyone excited after knocking off Seattle but have played like garbage ever since. Backup quarterback Tanner McKee looked somewhat good last week. I’d expect the same this week.
Lastly, Josh Allen will start for the Bills in Week 18. Then, it’ll be Mitch Trubisky for the rest of the game. But if Allen can help lead the Bills in the opening drive, that’ll be good momentum for closing out Week 18 with a win.
Parlay Odds: +424
Moneyline Parlay #2
- Leg 1: Jacksonville Jaguars Moneyline (+170)
- Leg 2: New York Jets Moneyline (-102)
- Leg 3: Detroit Lions Moneyline (-148)
The Colts are probably the worst team in the NFL right now. Joe Flacco and the Colts lost to the Giants last week in ugly fashion. Anthony Richardson will likely get the start this week, which is probably worse for this team. Look for Jacksonville to stun on the road to close out the season.
Meanwhile, it doesn’t sound likely Tua Tagovailoa will return for the Dolphins this week. It’s been a miserable season for the Jets, but they can crush the Dolphins’ playoff dreams with a win this weekend. That would be such a Jets thing to do.
I’m also siding with the Lions on Sunday Night Football. Many point out that the Lions played their starters in Week 17 when they didn’t have to and how that will hurt them in this game. But every team played their starters in Week 17, so it won’t be a factor. I’d also go as far as saying that the Lions have an all-around better defense.
Parlay Odds: +795