NFL Week 2 Early Odds, Picks & Predictions: Chargers vs. Chiefs (2022)

Here is our preview and best bet for the 2022 NFL Week 2 game between the Chargers vs. Chiefs.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

NFL Week 2 Early Odds, Picks & Predictions: Chargers vs. Chiefs

Los Angeles Chargers at Kansas City Chiefs

Check out our Chargers at Chiefs matchup page.

  • Kickoff: Thursday, Sept. 15, 2022, 8:15 pm ET
  • Location: Arrowhead Stadium
  • TV: Prime Video

Chargers at Chiefs: Consensus Lines

  • Spread: Chiefs -3.5
  • Over/Under: 54
  • Moneyline: Chiefs -182, Chargers +150

Kansas City Chiefs Trends

  • HC Andy Reid: 33-20 ATS (21.8% ROI) in division (with Chiefs only)
  • HC Andy Reid: 24-13 ATS (27.8% ROI) in Weeks 1-4 (with Chiefs only)
  • QB Patrick Mahomes: 13-8-1 ATS (19.5%) in primetime (including postseason)

Chiefs Notes

QB Patrick Mahomes was 30-of-39 for 360-5-0 passing in Week 1 as the Chiefs effortlessly scored 44 points. They’ve moved on from former No. 1 WR Tyreek Hill.

Chargers at Chiefs: Early Bet

  • Bet: Chiefs -3
  • Early Projection: -5.25
  • Odds: -110
  • Sportsbook: DraftKings
  • Date & Time: Sunday, Sept. 11, 10 p.m. ET
  • Units: 1.1
  • Limit: -4

Note: I first posted this pick in the BettingPros app on Sunday morning via the lookahead line of -3 (-110, DraftKings).


Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you're new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our How To Section - including How to Avoid the 7 Biggest Sports Betting Mistakes - or head to a more advanced strategy - like Thinking Like an Expert Sports Bettor - to learn more.

Try Premium for FREE in our mobile app