NFL Week 2 Odds, Picks & Predictions for Every Game Sunday (2022)
Here are our picks and leans for each NFL game of Week 2.
Prop Bet Analyzer: View top-rated props and historical prop performance by player >>
Jets vs. Browns
The Jets will look to rebound after a loss to the Ravens last week. The Browns held McCaffrey to 33 yards rushing last week in their win over the Panthers. The Jets were also stout against the run, allowing three yards per carry last week. However, both teams allowed over 12 yards per completion last week, with Jacoby Brissett completing 59.2% of his passes for 147 yards as a game manager, as the team ran for 217 yards. He should have an easier time throwing the ball this week. Flacco, meanwhile, could have a little more success through the air, but if he must throw 59 times like last week, it could be a tough day. Both teams will look to run the ball, but the Browns will likely have more success in a low-scoring affair.
Pick: Browns -6.5 | u39.5
Commanders vs. Lions
The Commanders travel to Detroit to take on the Lions in Week 2. Washington, in their win over Jacksonville, was able to make some big plays through the air, but QB Carson Wentz also threw two interceptions. Meanwhile, the Lions were beaten in the air and on the ground by dynamic QB Jalen Hurts in their loss to the Eagles. Wentz doesn't pose the same kind of ground threat as Hurts but can hurt Detroit through the air if they are unable to get pressure. Meanwhile, the Lions running game was excellent against a strong Eagles front seven, which could be a problem for a Washington defense that gave up 6.8 yards per carry in Week 1. Both teams should be able to move the ball and it may come down to which quarterback makes the least amount of mistakes.
Picks: Lean Lions -1.5 | o48.5
Buccaneers vs. Saints
The Tampa Bay Buccaneers visit the division rival New Orleans Saints in a battle of NFC South favorites. The Saints were able to rally on the road versus the Falcons and usher in the Dennis Allen/Jameis Winston era with a victory. Despite looking anemic for much of the contest, the Saints’ offense showed potential late in the game versus Atlanta.
The Tampa Bay offense, however, looked league-average at best. They had success running the ball against an exploitable Cowboys run defense, but the unit lacked the explosiveness which propelled it to the NFL's elite in past seasons.
The Saints have been QB Tom Brady's kryptonite since his arrival in Tampa, I'll gladly take the points with the Saints in their home opener.
Picks: Saints +2.5 | lean u44
Panthers vs. Giants
The Panthers were one of the worst teams against the run last week, and the Giants had the most rushing yards in Week 1. Saquon Barkley should pick up right where he left off against the Titans when he scored the game-winning two-point conversion. He also ran the ball 18 times for 164 yards, an average of 9.1 yards per carry. The Panthers gave up 5.6 yards per attempt against Nick Chubb and the Browns last week.
Baker Mayfield was sacked four times by the Browns last week, and Daniel Jones was sacked five times. The Giants have a better chance at pressuring the quarterback, especially if Kayvon Thibodeaux suits up, but the secondary will need help after allowing 13.3 yards per completion last week. Mayfield threw for 12.9 yards per completion; he may connect on a few deep balls.
Picks: Giants -1.5 | Lean o43.5
Patriots vs. Steelers
As they head to Pittsburgh, the Patriots look to forget their woeful Week 1 start. On the bright side, the Pats’ defense allowed only 59 yards of rushing at a 2.57 yards per carry rate. They will have to keep Harris contained, as the Steelers will almost surely utilize Najee more than the 10 rushes he saw in Week 1.
For the Steelers, the loss of T.J. Watt will impact their potent defense, but how much? With six sacks and three interceptions from other defenders (including one pick-six), the Steelers might just have enough talent to cover for Watt while his pec recovers.
Nonetheless, with New England down to -2 even with the Steelers receiving 65+% of the spread bets, be watching for even more late-line movement as the game approaches.
Picks: Patriots -2 | Lean o40
Colts vs. Jaguars
The Colts travel to Jacksonville for a Week 2 AFC South matchup. Indianapolis continued their trend of slow starts with a tie to Houston in which they were only able to muster a field goal through the first three quarters. Matt Ryan fumbled four times, losing only one, and threw an interception in his Colts debut, reminding fans of Carson Wentz. On the other side of the ball, Jacksonville will pose a bigger threat offensively for Indianapolis, as they were able to move the ball effectively on the ground in their Week 1 matchup with the Commanders to the tune of 6.8 yards per carry. The Colts have the firepower to exploit the Jaguars’ defense, but if they start slow again, they may find it too difficult to turn it on late again in the Florida humidity.
Picks: Jaguars +3.5 | Lean u45
Dolphins vs. Ravens
The Miami Dolphins visit the Baltimore Ravens in one of the most exciting matchups of Week 2. After a Week 1 beatdown of their division rival Patriots, the Dolphins are on the cusp of being perceived as an AFC contender were they to upset Baltimore in their home opener.
The questions surrounding QB Lamar Jackson's future have shrouded the Ravens' season in a degree of both uncertainty and urgency. The Ravens crushed the Jets in Week 1, but that is hardly an indictment of their ranks in the 2022 NFL hierarchy. Baltimore's victory over opposing QB Joe Flacco was expected, and so will this one.
Fans should be encouraged by Miami’s Week 1 performance. However, a road contest versus the Ravens is hardly a fertile environment for QB Tua Tagovailoa, or rookie HC Mike McDaniel. Trust the former league MVP in the most crucial season of his career.
Picks: Ravens -3.5 | lean u44.5
Falcons vs. Rams
The Rams did not look like the defending champs in their opener against the Bills. They were last in the league in yards per completion with 6.6, while Matthew Stafford threw three interceptions and got sacked seven times. On the ground, they only gained 52 yards for a 2.9 average. Clearly, offensive line play is a problem for them. Atlanta sacked Jameis Winston four times last week and should get pressure again this week. Unfortunately, they gave up 7.9 yards per carry last week, so the Rams line may be able to gain momentum run blocking.
Marcus Mariota ran for 72 yards and a TD while throwing for 215 yards through the air in Week 1. He did lose a fumble and may have more turnover issues this week, as the Rams’ defense forced four turnovers last week against the Bills’ elite offense and could generate a few more this week.
Picks: Lean Rams -10 | Lean u46.5
Seahawks vs. 49ers
Geno Smith and the Seahawks look to carry momentum from Week 1 as they travel to San Francisco. The Seahawks benefitted from two costly Broncos goal-line fumbles on their way to an outright win, while the 49ers found themselves in a sloppy game at Soldier Field where they found defeat at the hands of Chicago.
With the injury to Elijah Mitchell, the 49ers start with a disadvantage in their run attack and will look to Jeff Wilson and others to pull their weight against a Seattle defense that allowed 5.15 yards per carry in Week 1. On the other side, the Seahawks will have to find their running game if they look to compete. Rushing for only 76 total rushing yards in Week 1, they now face a dynamic front four led by Nick Bosa. Let's also not forget about the hopeful return of veteran TE George Kittle.
Picks: San Fransisco -9.5 | lean o41.5
Bengals vs. Cowboys
The Cincinnati Bengals visit the Dallas Cowboys in an interconference matchup featuring two of the NFL's best from a season ago. Were it not for an unfortunate injury to Dallas QB Dak Prescott, this would have been projected to be one of the most competitive games of the Week 2 slate. Many expect this contest now to be a blowout.
Both of these teams disappointed in Week 1, and a victory is suddenly crucial for each of these playoff-hopeful teams. A path to victory is unlikely for the Cowboys with backup Cooper Rush slated to start, but if Pittsburgh can win outright in Cincinnati, the Cowboys can certainly cover the spread on their home field.
This line was Dallas -1.5 prior to the Week 1 outcomes. Is the injury to Dak Prescott really so significant that it should justify nine points of line movement?
Picks: Cowboys +7.5 | lean u41.5
Texans vs. Broncos
The Broncos will play host to the Texans in Russel Wilson's first home game in Denver. They look to move past the regretful play-calling in their one-point defeat at Seattle in Week 1, and to do that, the Broncos must establish their two-headed run game with Williams and Gordon in the backfield. Houston gave up 177 rushing yards to the Colts last week, and the Broncos can look to exploit that in Week 2.
While the Texans put up over 300 yards of offense in the season opener, they face a defense that only allowed 39 yards of total offense in the second half against the Seahawks. Look for the Broncos to continue the defensive momentum and for them to get into the win column at home.
Picks: Lean Denver -10 | Lean u45.5
Cardinals vs. Raiders
Arizona travels to Las Vegas after both teams put up performances they'd like to forget in Week 1. The Cardinals’ defense was overmatched by the dynamic Chiefs' offense. The Raiders will look to try and match that performance, but questions still linger about their ability to run the ball, managing just 64 yards on the ground in the opener. Derek Carr will need to be better as well, as when he wasn't finding new WR Davante Adams, he was throwing the ball to the Chargers’ defense. If the Cardinals can generate some pressure, it could be another long day for Carr.
Kyler Murray will need to make some plays on a Raiders pass defense that was not very impressive in Week 1 after a poor 2021. The Las Vegas defense has a knack for allowing teams to stay in games, and Murray is capable of taking advantage of that.
Picks: Cardinals +5.5 | u51.5
Bears vs. Packers
The Bears beat the 49ers last week in a muddy, wet game at Soldier Field. Justin Fields only threw 17 passes in the game, while the team had 37 rushing attempts. The play-calling could be quite different this week since the weather dictated it last week. They only averaged 2.7 yards per carry in the season opener, so they will look to capitalize against the Packers' pass defense that just let Justin Jefferson run free all day in Week 1.
The Packers were held to seven points by the Vikings in their Week 1 loss, as Aaron Rodgers only threw for 195 yards and an interception. He was without his number-one target, Allen Lazard, who will be returning this week. His return should help tremendously, as a rookie, Christian Watson, dropped a would-be TD last week. The Packers averaged 6.2 yards per carry and will look to run against a Bears' defense that allowed 4.8 yards per attempt.
Picks: Bears +10 | Lean o41.5
Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts
Whether you're new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our How To Section - including How to Avoid the 7 Biggest Sports Betting Mistakes - or head to a more advanced strategy - like Thinking Like an Expert Sports Bettor - to learn more.