NFL Week 2 Odds, Picks & Predictions: Moneyline Underdog Bets (2022)

In Week 1, the underdogs went 6-9-1. The Steelers, Giants, Bears, Browns, Vikings, and Seahawks won outright, and the Texans were able to hold on for a tie against the Colts in a game they were leading until late. Listed below are the moneyline odds for Week 2 and three underdogs that may be worth a longshot bet.

Moneyline underdogs for Week 2 with odds from FanDuel Sportsbook:

• Pittsburgh Steelers (vs New England Patriots) (+102)
• Minnesota Vikings (@ Philadelphia Eagles) (+108)
• Washington Commanders (@ Detroit Lions) (+110)
• Carolina Panthers (@ New York Giants) (+118)
• New Orleans Saints (vs Tampa Bay Buccaneers) (+134)
• Miami Dolphins (@ Baltimore Ravens) (+156)
• Los Angeles Chargers (@ Kansas City Chiefs) (+160)
• Jacksonville Jaguars (vs Indianapolis Colts) (+168)
• Arizona Cardinals (@ Las Vegas Raiders) (+198)
• New York Jets (@ Cleveland Browns) (+210)
• Dallas Cowboys (vs Cincinnati Bengals) (+260)
• Seattle Seahawks (@ San Francisco 49ers) (+310)
• Tennessee Titans (@ Buffalo Bills) (+330)
• Chicago Bears (@ Green Bay Packers) (+360)
• Houston Texans (@ Denver Broncos) (+370)
• Atlanta Falcons (@ Los Angeles Rams) (+430)

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Small Long Shot (odds between +101 to +150)

The New Orleans Saints play the Tampa Bay Buccaneers in their home opener in Week 2. The Saints haven't lost to the Buccaneers in the regular season since September 2018. That timespan includes the Tom Brady era, where the Saints are 4-0 in the regular season vs Brady with wins of 9-0, 36-27, 38-3, and 34-23.

In week 1, the Saints got off to a slow start on the road but were able to outscore the Falcons 17-3 in the fourth quarter to complete the comeback and win 27-26. Jameis Winston and Michael Thomas both returned from injury and were able to connect for two touchdowns in the win.

The Buccaneers were able to win in Dallas to also start their season 1-0. The 19-3 win was an ugly game where Dak Prescott left in the fourth quarter injured. How the offensive line would hold up has been a major question for the Buccaneers this season after the departures of Ali Marpet to retirement, Ryan Jensen to injury, and Alex Cappa to free agency. Against the Cowboys, they allowed two sacks, but both to Micah Parsons, who will be in the running for the Defensive Player of the Year award. Their job doesn't get much easier this week where they will have to try to keep Brady upright against Cam Jordan and Marcus Davenport.

Betting against Tom Brady isn't usually profitable, but in the case of the Saints in the regular season, even as weird as it is to say, Brady has really struggled.

Pick: New Orleans Saints (+134)

Medium Long Shot (odds between +151 to +250)

I picked the Jacksonville Jaguars to beat the Washington Commanders as a week 1 longshot, I picked them in a survivor pool, I picked them to win the AFC South, and after a Week 1 loss, I am picking them as a longshot again. Maybe I'm too bullish on the Jaguars this year, but the young talent and Superbowl-winning coach just feel like a good combination.

The Jaguars’ young defensive investments are starting to pay off. Travon Walker had a sack, a tackle for a loss, a pass deflection, and an interception. Tyson Campbell had an interception and a pass deflection, and Josh Allen was disruptive in the backfield with two tackles for a loss and a quarterback hit.

The free agent additions on offense played a huge role in Week 1 as Christian Kirk and Zay Jones combined for 12 catches and 182 yards. James Robinson, who returned from a late-season Achilles injury, scored two touchdowns and doesn't appear to have a lasting impact from the often career-altering injury. Travis Etienne Jr. returned from injury and only had 4 carries for 47 yards but averaged 11.8 yards-per-carry with a long rush of 27 yards. If Trevor Lawrence can grow under Doug Pederson, it appears his weapons on offense are pretty strong, and this team should be able to win some games.

The Indianapolis Colts went down to Houston and were barely able to squeak out a tie. The Colts were down 20-3 in the fourth quarter before outscoring the Texans 17-0 to force overtime. The game ended in a tie in what was the largest spread of the week, with the Texans being +320 against the Colts. Jonathan Taylor and Michael Pittman are stars and will be a problem for any team they face. Outside of these two, however, the Colts do not have a lot of depth as far as their offensive weapons go. Matt Ryan was the second leading rusher with 12 yards. If either player has a down game, this team may struggle to move the ball.

The Colts will be on the road for their second straight game to start the season after struggling in Houston in week 1. The Jaguars were leading in the fourth quarter but were not able to hold on. Had the games ended ten minutes earlier, the results would have been the opposite. I am trusting Doug Pederson to get his young players ready to focus on closing out games.

Pick: The Jacksonville Jaguars (+168)

Large Long Shot (odds of +251 and up)

In an emotional Monday night game in Seattle, the Seahawks were able to squeeze out a 17-16 win in Russell Wilson's return. There is a good chance this was the game the Seahawks had circled on the calendar ever since they traded Wilson to the Broncos this summer, and they may not play up to that level again. However, this Seahawks team looked like they were living up to Pete Carroll's vision of a team that can control the ball and plays stout defense.

The Seahawks defense was able to be incredibly disruptive in the win. They got after Russell Wilson with two sacks and eight quarterback hits. They were also able to compile six tackles for loss. Geno Smith was very efficient in completing 23 of 28 pass attempts for 195 yards, two touchdowns, and a 119.5 rating. Defense and steady quarterback play were what defined the Seahawks during the period they were having their most success in the early 2010s. I don't expect the Seahawks to be at that level again this year, but there are signs they are building in that same model.

The San Francisco 49ers went to Chicago and surprisingly walked away with the loss against the Bears to start 0-1 on the season. The Trey Lance era started on a low, but it is difficult to really gauge how much stock to put into this one game. The treacherous weather in Chicago may have had a significant impact on the game, but the end result was still a loss to a team that many believe will be in contention for the first overall pick next year.

Lance completed less than 50% of his passes with a stat line of 13/28 for 164 yards, 0 touchdowns, and 1 interception, but led the team with 54 rush yards. Until we see what Lance can do as a starter, I think there could be value in betting against the 49ers while they are still being given high favorite odds.

Pick: The Seattle Seahawks (+310)

The Long Shot Parlay for Week 1:

• New Orleans Saints (+134)
• Jacksonville Jaguars (+168)
• Seattle Seahawks (+310)

Parlay: +2471 (FanDuel Sportsbook)

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