NFL Week 4 Early Odds, Picks & Predictions: Rams vs. 49ers (2022)
Here are some trends for Week 4 as well as an early best bet for Bears vs. Giants I like based on the current lines in the market and my early personal projections, which I will update throughout the week along with our premium BettingPros spread projections.
And check out a few of my other favorite early bets for Week 4:
Prop Bet Analyzer: View top rated props and historical prop performance by player >>
NFL Week 4 Early Odds, Picks & Predictions: Rams vs. 49ers (2022)
Note: These aren't all the trends I'm seeing and all the early bets I like. These are just a few of them. For more of my early Week 4 bets, check out the BettingPros App.
All lines and odds are from the BettingPros NFL odds page and as of Sept. 25. All the historical trends information is from Action Network and goes back to 2003. Abbreviations: Against the spread (ATS), return on investment (ROI), moneyline (ML).
All odds are from the following sportsbooks.
Click on the sportsbook links above to check out their promotional offers. If you're not taking advantage of these deals, you're basically admitting to yourself that you hate money.
Los Angeles Rams at San Francisco 49ers
Check out our Rams at 49ers matchup page.
- Kickoff: Monday, Oct. 3, 2022, 8:15 pm ET
- Location: Levi’s Stadium
- TV: ESPN
Rams at 49ers: Consensus Lines
- Spread: 49ers -1.5
- Over/Under: 47
- Moneyline: 49ers -125, Rams +105
San Francisco 49ers Trends
Before the 49ers as favorites play Broncos on SNF in Week 3.
- HC Kyle Shanahan: 17-25-1 ATS (14.4% ROI for faders) as favorite
- HC Kyle Shanahan: 15-22-1 ATS (14.9% ROI for faders) at home
- HC Kyle Shanahan: 7-15-1 ATS (29.7% ROI for faders) as home favorite
Rams at 49ers: Early Bet
- Bet: Rams +2
- Early Projection: Pick’Em
- Odds: -110
- Sportsbook: DraftKings
- Date & Time: Sunday, Sept. 25, 9 p.m. ET
- Units: 1.1
- Limit: Rams +1.5
Note: I first posted this pick in the BettingPros app via the lookahead line of +2.5 (-110, Caesars).
Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts
Whether you're new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our How To Section - including How to Avoid the 7 Biggest Sports Betting Mistakes - or head to a more advanced strategy - like Thinking Like an Expert Sports Bettor - to learn more.