NFL Week 5 Early Odds, Picks & Predictions: Colts vs. Broncos (2022)

We’re here to get you ready for Week 5. You can check out all of our early Week 5 NFL content below, including our early picks and predictions for the week ahead. And here’s a closer look at the NFL Week 5 matchup: Colts vs. Broncos.

Prop Bet Analyzer: View top-rated props and historical prop performance by player >>

NFL Week 5 Early Odds, Picks & Predictions: Colts vs. Broncos

Thursday Night Football features a game between two of the most inconsistent teams in the NFL. Two weeks ago, the Colts took down the Chiefs, then they followed it up with a home loss to the Titans. Meanwhile, the Broncos finally found some offense, scoring more than 20 points for the first time this year, yet they lost to the previously 0-3 Raiders. 

This number opened right at the key number, with Denver favored by three. These two teams are each 1-3 against the spread this season, so neither side will likely find much support from the betting public. However, the Broncos have looked terrible offensively at times this season, and they just lost Javonte Williams for the season. 

The line won't move much, but any movement will be important for a game that should be decided by a field goal either way.

Current Line: Broncos -3

Predicted Final Line: Broncos -2.5


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

View 5-star bets and historical prop performance by player with our Prop Bet Analyzer >>

Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you're new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our How To Section - including How to Avoid the 7 Biggest Sports Betting Mistakes - or head to a more advanced strategy - like Thinking Like an Expert Sports Bettor - to learn more.

Try Premium for FREE in our mobile app