NFL Week 5 Early Odds, Picks & Predictions: Steelers vs. Bills (2022)

We’re here to get you ready for Week 5. You can check out all of our early Week 5 NFL content below, including our early picks and predictions for the week ahead. And here’s a closer look at the NFL Week 5 matchup: Steelers vs. Bills.

Prop Bet Analyzer: View top-rated props and historical prop performance by player >>

NFL Week 5 Early Odds, Picks & Predictions: Steelers vs. Bills

The largest spread of the week belongs to the Steelers vs. the Bills. Kenny Pickett will likely make his first start in the NFL after scoring two touchdowns and throwing three interceptions in relief against the Jets. Meanwhile, the Bills will look for their first lopsided victory since Week 2 after two contentious games against the Dolphins and Ravens.

Despite how large this line is and how good the Steelers’ defense can be, it’s hard to imagine that the public will back the Steelers in this one. The Bills have won two games this season by three scores or more, and there is no reason to think they won’t blow out the Steelers in this one. If you’re on the Bills, the line likely won’t be better than this.

Current Line: Bills -14

Predicted Final Line: Bills -15.5


What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

View 5-star bets and historical prop performance by player with our Prop Bet Analyzer >>

Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you’re new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our How To Section — including How to Avoid the 7 Biggest Sports Betting Mistakes â€” or head to a more advanced strategy — like Thinking Like an Expert Sports Bettor â€” to learn more.

Try Premium for FREE in our mobile app