NFL Week 5 Odds, Picks & Predictions: Chargers vs. Browns (2022)

We’re here to get you ready for Week 5. Here’s a closer look at the NFL Week 5 matchup: Chargers vs. Browns.

Here are other Week 5 game previews:

• Giants vs. Packers
• Steelers vs. Bills
• Bears vs. Vikings
• Lions vs. Patriots
• Seahawks vs. Saints
• Dolphins vs. Jets
• Falcons vs. Buccaneers
• Titans vs. Commanders
• Texans vs. Jaguars
• 49ers vs. Panthers
• Cowboys vs. Rams
• Eagles vs. Cardinals
• Bengals vs. Ravens
• Raiders vs. Chiefs

And check out our best bets of the week from our analysts:

• Matthew Freedman's NFL Week 5 Early Bets and Trends
• NFL Week 5 Early Lines vs. Line Movement Predictions
• Video: NFL Week 5 Early Odds, Picks & Predictions

Prop Bet Analyzer: View top-rated props and historical prop performance by player >>

NFL Week 5 Odds, Picks & Predictions: Chargers vs. Browns

The Chargers will likely be without Keenan Allen, who has been dealing with a hamstring injury. He would be a big help against the Browns, who allow 12.2 yards per completion. They had not allowed a passing TD since week four when they allowed four to Joe Flacco and the Jets. Even without Allen, Herbert should be able to find holes in this defense since they have yet to see a quarterback of Herbert's caliber this season. They have also allowed two rushing TDs in three out of four games, so Austin Ekeler should find the paydirt coming off a two-TD performance last week.

The Chargers allow 5.4 yards per rush attempt, and they are facing one of the run-heaviest teams in the league. The Browns have 149 rushing attempts this season, which is second behind the Eagles. Chubb should have success, but the Chargers need this win more.

Chargers -2.5, Lean o47.5

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