NFL Week 5 Odds, Picks & Predictions: Lions vs. Patriots (2022)

We’re here to get you ready for Week 5. Here’s a closer look at the NFL Week 5 matchup: Lions vs. Patriots.

Here are other Week 5 game previews:

• Giants vs. Packers
• Steelers vs. Bills
• Chargers vs. Browns
• Bears vs. Vikings
• Seahawks vs. Saints
• Dolphins vs. Jets
• Falcons vs. Buccaneers
• Titans vs. Commanders
• Texans vs. Jaguars
• 49ers vs. Panthers
• Cowboys vs. Rams
• Eagles vs. Cardinals
• Bengals vs. Ravens
• Raiders vs. Chiefs

And check out our best bets of the week from our analysts:

• Matthew Freedman's NFL Week 5 Early Bets and Trends
• NFL Week 5 Early Lines vs. Line Movement Predictions
• Video: NFL Week 5 Early Odds, Picks & Predictions

Prop Bet Analyzer: View top-rated props and historical prop performance by player >>

NFL Week 5 Odds, Picks & Predictions: Lions vs. Patriots

Detroit brings one of the most potent offensive attacks into this matchup with the Patriots. Regardless of who is carrying the ball, the Lions have been extremely effective moving the ball on the ground. They'll try to continue that trend against the 31st ranked run defense per DVOA.

On the other end, the Patriots have the same advantage, with their two-headed attack, running against the 32nd ranked run defense per DVOA in Detroit. With both teams being able to move the ball on one another on the ground, this game could turn out to be the Lions' first under if long methodical drives develop.

The final score could come down to which quarterback makes plays when needed. With Mac Jones questionable, the Lions get the edge here. Even with injuries all over the roster, Goff has found ways to make plays and I expect that to continue Sunday.

Lions +3, u45.5

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