NFL Week 5 Same Game Parlay Picks & Predictions: 49ers vs. Panthers (2022)

Each week, I'll be providing my favorite Sunday parlay, along with my favorite same-game parlay options for each game. Without further ado, here are this week's parlay picks for 49ers vs. Panthers.

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NFL Week 5 Same Game Parlay Odds, Picks & Predictions: 49ers vs. Panthers

San Francisco 49ers -6.5 at Carolina Panthers, Total 39 

  • Under 39
  • Baker Mayfield to throw an INT
  • Christian McCaffrey under 52.5 rushing yards
  • Odds: +502

This game is absolutely disgusting, and defenses should reign supreme. San Francisco is the top-ranked defense in DVOA, while Carolina is 12th. With Baker Mayfield and Jimmy Garoppolo under center, expect a lot of running and a fast running clock. Oh, and Mayfield will surely make a mistake or two against this 49ers defense.


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Player props refer to wagers that bettors can make based on player performance in a specific game. The majority of player props are built around the most common statistical benchmarks for a specific sport such as yards and touchdowns in football. Most player props are straight over/under plays that open at or near -110 and are adjusted based on where the money lands. Examples of baseball player prop bets include over/under 4.5 strikeouts for a starting pitcher or over/under 1.5 total bases for a hitter.

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