NFL Week 6 Early Odds, Picks & Predictions: Bills vs. Chiefs (2022)

For the past few NFL seasons, each Sunday night I've written an early bets piece highlighting some applicable trends I've noticed for the upcoming week.

I'm not a trends bettor, but I find that historical situational data helps me identify spots I should consider further when analyzing games.

So here are some trends for Week 6 as well as an early bet I like based on the current lines in the market and my early personal projections, which I will update throughout the week along with our premium BettingPros spread projections.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

Note: These aren't all the trends I'm seeing and all the early bets I like. These are just a few of them. For more of my early Week 6 bets, check out the BettingPros App.

All lines and odds are from the BettingPros NFL odds page and as of Oct. 9. All the historical trends information is from Action Network and goes back to 2003. Abbreviations: Against the spread (ATS), return on investment (ROI), moneyline (ML).

All odds are from the following sportsbooks.

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NFL Week 6 Early Odds, Picks & Predictions

Buffalo Bills at Kansas City Chiefs

Check out our Bills at Chiefs matchup page. Written before Chiefs play on Monday Night Football in Week 5.

  • Kickoff: Sunday, Oct. 16, 2022, 4:25 pm ET
  • Location: GEHA Field at Arrowhead Stadium
  • TV: CBS

Bills at Chiefs: Consensus Lines

  • Spread: Bills -1.5
  • Over/Under: 53.5
  • Moneyline: Bills -125, Chiefs +105

Kansas City Chiefs Trends

  • QB Patrick Mahomes: 7-0-1 ATS (85.4% ROI) as underdog
  • QB Patrick Mahomes: 6-2 ML (89.3% ROI) as underdog

Bills at Chiefs: Early Bet

  • Best Line: Chiefs +2 (-110, Caesars)
  • Personal Projection: Chiefs -1.25
  • Limit: Chiefs +1

Note: I first posted this pick in the BettingPros app via the lookahead line of +1.

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