NFL Week 6 Early Odds, Picks & Predictions: Chiefs vs. Bills (2022)

We’re here to get you ready for Week 6. You can check out all of our early Week 5 NFL content below, including our early picks and predictions for the week ahead. And here’s a closer look at the NFL Week 6 matchup: Chiefs vs. Bills.

Prop Bet Analyzer: View top-rated props and historical prop performance by player >>

NFL Week 6 Early Odds, Picks & Predictions: Chiefs vs. Bills

Kansas City Chiefs and Buffalo Bills over 54 (-110)

This AFC Divisional Round rematch could be a future playoff matchup with how well these teams are playing.

Josh Allen looks like an MVP candidate as he leads the league in passing yards (1,651) and is second in points per game.

Right next to Allen in the MVP race is Patrick Mahomes, as his stellar performance on Monday night has him leading the league with 15 touchdowns and a 110.5 passer rating. His Kanas City is also the offense that leads the league in points (31.8).

The recent history between these teams has brought exciting and high-scoring games. This includes last season’s playoffs with a 28-point fourth quarter and a game-winning overtime touchdown by Kansas City. Their last three matchups have gone over 57 total points, and with how well each offense is playing, we’re looking forward to another shootout.


What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

View 5-star bets and historical prop performance by player with our Prop Bet Analyzer >>

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