Video: NFL Week 6 Early Picks & Line Movement Predictions (2024)

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Joe Pisapia and Andrew Erickson are back for Week 6 of the NFL season to break down every game and offer insights into potential upsets, value picks and how the line for each matchup will move. How did you do in Week 5? What are you betting in Week 6? Let us know in the comments below!

  • San Francisco 49ers @ Seattle Seahawks: San Francisco, coming off a tough loss, looks to bounce back against a Seattle team that also suffered a defeat. Despite being three-point underdogs at home, Seattle will face a fired-up 49ers squad. The discussion highlights San Francisco's ability to step up in critical games, while Seattle has struggled against tougher competition.
  • Jacksonville Jaguars vs. Chicago Bears (London): Though Chicago is listed as the home team, this one's in London, where Jacksonville thrives. With rookie QB intrigue and Jacksonville riding momentum from their first win, this matchup is packed with potential value. The Jaguars’ experience in London and their rising form make them an under-the-radar pick.
  • Tampa Bay Buccaneers @ New Orleans Saints: Tampa Bay, with extra rest after their Thursday night loss, enters as a value play against New Orleans. The Buccaneers need to win to stay competitive in the NFC South, and Baker Mayfield has been playing well, apart from one tough outing. Betting on Tampa Bay here could offer solid value, especially with the Saints' unpredictability.

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What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

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