NFL Week 6 Predictions & Best Bets: Seahawks vs. Cardinals (2022)
We’re here to get you ready for Week 6. Here’s a closer look at the NFL Week 6 matchup: Seahawks vs. Cardinals.
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NFL Week 6 Odds, Picks & Predictions: Seahawks vs. Cardinals
Arizona Cardinals at Seattle Seahawks
Check out our Cardinals at Seahawks matchup page.
- Kickoff: Sunday, Oct. 16, 2022, 4:05 pm ET
- Location: Lumen Field
- TV: FOX
Cardinals at Seahawks: Consensus Lines
- Spread: Cardinals -2.5
- Over/Under: 50.5
- Moneyline: Cardinals -144, Seahawks +122
Cardinals at Seahawks: Betting Percentages
Data from Action Network and as of Oct. 12
- Spread: Cardinals – 49% bets, 53% money
- Over/Under: Over – 48% bets, 70% money
- Moneyline: Seahawks – 46% bets, 78% money
Cardinals at Seahawks: Injuries
Cardinals: Week 6 Injury Report
| Player | Position | Injury | Wed |
| James Conner | RB | Ribs | DNP |
| Rodney Hudson | OL | Knee | DNP |
| Trayvon Mullen | CB | Hamstring | DNP |
| Matt Prater | K | Right Hip | DNP |
| Darrel Williams | RB | Knee | DNP |
| Max Garcia | OL | Toe | LP |
| Dennis Gardeck | LB | Ankle | LP |
| Sean Harlow | OL | Ankle | LP |
| D.J. Humprhies | OL | Hamstring | LP |
| Rashard Lawrence | DL | Hand | LP |
| Justin Pugh | OL | Elbow | LP |
Cardinals: IR, PUP & Out
| Player | # | Pos | Status |
| Colt McCoy | 12 | QB | IR-Return |
| Antoine Wesley | 13 | WR | IR-Return |
| Tae Daley | 48 | S | IR |
| Cody Ford | 72 | OL | IR |
| Marquis Hayes | 78 | OL | IR |
| Joshua Miles | 66 | OL | IR |
| Nick Vigil | 59 | ILB | IR |
| Jonathan Ward | 29 | RB | IR |
| Charles Washington | 28 | S | IR |
| DeAndre Hopkins | 10 | WR | Suspended |
Seahawks: Week 6 Injury Report
| Player | Position | Injury | Wed |
| Dee Eskridge | WR | Illness | DNP |
| Penny Hart | WR | Hamstring | DNP |
| Dareke Young | WR | Quadriceps | DNP |
| Shelby Harris | DE | Hip | DNP |
| Gabe Jackson | G | Knee/Hip | DNP |
| Rashaad Penny | RB | Ankle | DNP |
| Al Woods | NT | Knee | DNP |
| Marquise Goodwin | WR | Knee/Back | FP |
| Kenneth Walker | RB | Shoulder | FP |
| Justin Coleman | CB | Calf | FP |
Seahawks: IR, PUP & Out
| Player | Pos | Status |
| L.J. Collier | DE | IR-Return |
| Jamal Adams | SS | IR |
| Travis Homer | RB | IR |
| Darryl Johnson | LB | IR |
| Tyler Ott | LS | IR |
| John Reid | CB | IR |
| Alton Robinson | LB | IR |
| Tyreke Smith | LB | IR |
| Cody Thompson | WR | IR |
| Tre Brown | CB | PUP |
| Ben Burr-Kirven | LB | PUP |
| Jon Rhattigan | LB | PUP |
Cardinals at Seahawks: Notable Trends
Data from Action Network and goes back to 2003. Abbreviations: Against the spread (ATS), return on investment (ROI), moneyline (ML).
Cardinals Trends
- 2022 Cardinals: 3-2 ATS (14.5% ROI)
- HC Kliff Kingsbury: 19-6-2 ATS (44.2% ROI) on road
- HC Kliff Kingsbury: 8-14 ATS (22.5% ROI for faders) as favorite
Seahawks Trends
- 2022 Seahawks: 2-3 ATS (15.4% ROI for faders)
- HC Pete Carroll: 55-40-3 ATS (12.7% ROI) at home
- HC Pete Carroll: 43-28-3 ATS (17.6% ROI) as underdog
- HC Pete Carroll: 16-8 ATS (31.0% ROI) as home underdog
Cardinals at Seahawks: Team Statistics
Advanced data from RBs Don’t Matter and Football Outsiders. Basic stats from Pro Football Reference. Regular season only. Abbreviations: Expected Points Added (EPA), Success Rate (SR), Defense-Adjusted Value Over Average (DVOA).
Cardinals Offense vs. Seahawks Defense
| Metric | Offense | Rank | Defense | Rank | Offense Edge |
| EPA per Play | 0.006 | 18 | 0.173 | 31 | 13 |
| Total SR | 44.2% | 17 | 46.2% | 23 | 6 |
| Total DVOA | -5.6% | 23 | 15.4% | 31 | 8 |
| Dropback EPA | 0.017 | 19 | 0.307 | 32 | 13 |
| Dropback SR | 43.9% | 21 | 50.0% | 28 | 7 |
| Pass DVOA | -0.8% | 23 | 31.4% | 31 | 8 |
| Adj. Sack Rate | 4.7% | 7 | 5.1% | 28 | 21 |
| Rush EPA | -0.014 | 14 | 0.023 | 25 | 11 |
| Rush SR | 44.7% | 8 | 41.9% | 17 | 9 |
| Rush DVOA | -3.5% | 16 | 0.0% | 24 | 8 |
| Adj. Line Yards | 4.58 | 11 | 5.12 | 30 | 19 |
| Yards per Play | 4.9 | 26 | 6.6 | 32 | 6 |
| Points per Game | 21 | 18 | 30.8 | 31 | 13 |
Seahawks Offense vs. Cardinals Defense
| Metric | Offense | Rank | Defense | Rank | Offense Edge |
| EPA per Play | 0.12 | 4 | 0.062 | 24 | 20 |
| Total SR | 47.1% | 9 | 50.5% | 31 | 22 |
| Total DVOA | 21.3% | 1 | 8.6% | 26 | 25 |
| Dropback EPA | 0.173 | 4 | 0.177 | 28 | 24 |
| Dropback SR | 52.2% | 3 | 53.3% | 32 | 29 |
| Pass DVOA | 45.1% | 1 | 19.6% | 27 | 26 |
| Adj. Sack Rate | 6.7% | 17 | 3.4% | 32 | 15 |
| Rush EPA | 0.024 | 6 | -0.139 | 7 | 1 |
| Rush SR | 37.9% | 23 | 45.5% | 24 | 1 |
| Rush DVOA | 5.3% | 12 | -9.1% | 12 | 0 |
| Adj. Line Yards | 4.52 | 15 | 4.68 | 22 | 7 |
| Yards per Play | 6.6 | 2 | 5.9 | 22 | 20 |
| Points per Game | 25.4 | 7 | 24.6 | 22 | 15 |
Cardinals at Seahawks: Quarterback Statistics
Data from RBs Don’t Matter, Pro Football Reference, ESPN and NFElo. Abbreviations: Completion Percentage Over Expectation (CPOE), Adjusted Yards per Attempt (AY/A), Adjusted Total Quarterback Rating (QBR), Quarterback Elo Value (QB Elo). 2022 data: Min. 80 plays for EPA + CPOE. Min. 14 pass attempts per scheduled game for AY/A. Min. 20 action plays per game for QBR.
2022: Kyler Murray
| Metric | Output | Rank |
| EPA + CPOE | 0.051 | 21 |
| AY/A | 5.7 | 29 |
| QBR | 52.1 | 13 |
| ATS Value vs. Avg. | 2.3 | 7 |
Career: Kyler Murray
- AY/A: 7.0
- QB Elo per Game: 66.5
2022: Geno Smith
| Metric | Output | Rank |
| EPA + CPOE | 0.189 | 3 |
| AY/A | 8.9 | 2 |
| QBR | 74.8 | 4 |
| ATS Value vs. Avg. | 1.5 | 10 |
Career: Geno Smith
- AY/A: 6.3
- QB Elo per Game: -45.9
Key Matchup: Seahawks Pass Offense vs. Cardinals Pass Defense
Going back to last season, when he made three spot starts for the injured Russell Wilson, QB Geno Smith has a top-three 8.5 AY/A and 0.154 composite EPA + CPOE.
Right now the world is Smith’s kitchen, and he’s cooking. For the season, the Seahawks are top-four in most pass efficiency metrics, and the Cardinals defense is bottom-six.
| Metric | Offense | Rank | Defense | Rank | Offense Edge |
| Dropback EPA | 0.173 | 4 | 0.177 | 28 | 24 |
| Dropback SR | 52.2% | 3 | 53.3% | 32 | 29 |
| Pass DVOA | 45.1% | 1 | 19.6% | 27 | 26 |
It helps that he has a top-10 pass-catching unit anchored by WRs D.K. Metcalf and Tyler Lockett, who have a massive edge over an outmatched secondary in our FantasyPros unit power rankings.
| Rank | WRs & TEs | Opp Secondary | Secondary Rank | Edge |
|---|---|---|---|---|
| 10 | SEA | ARI | 30 | 20 |
As wild as this is to say — because we have Cardinals QB Kyler Murray ranked as the No. 9 player at his position — Smith has been every bit as good as (and maybe better than?) Murray through five games, thanks in large part to the playmaking support of his receivers and the play-calling support of his coaches.
Given how well Smith has played to open the year — and how bad the Cardinals secondary has been — it’s hard to see why the Seahawks are home underdogs, especially against a divisional opponent.
Best Line: Seahawks +3 (-125, Caesars)
First Recommended: Seahawks +3 (-125)
Personal Projection: Pick’Em
Limit: Seahawks +2
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