NFL Week 7 Early Odds, Picks & Predictions: Chiefs vs. 49ers (2022)

Last week, I suggested betting on -6.5 for the Buccaneers against the Steelers. I argued that the 6.5 key number wouldn’t be there after games were played on Sunday. That analysis was spot on. The Bucs are now -8 point favorites against the Steelers. That key number is now gone.

Here are three early spots for next week’s NFL slate. Below, let’s take a look at Chiefs vs. 49ers.

(Odds courtesy DraftKings Sportsbook)

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NFL Week 7 Early Odds, Picks & Predictions: Chiefs vs. 49ers

Kansas City Chiefs vs. San Francisco 49ers

This week, Patrick Mahomes is an underdog against the Buffalo Bills. This is the first time I’ve seen Mahomes as an underdog at home. What if the Chiefs earn a win against the Bills at home on Sunday?

The Chiefs would eventually become a three-or-more-point favorite against the 49ers, even on the road.

Meanwhile, the 49ers have the Atlanta Falcons on the road. If the 49ers earn a win in that game, it won’t have much of an effect on the odds in the following week. But if they lose, it certainly will.

It’s a win-win situation for the Chiefs if they can pull off an upset against Buffalo.

Bet: Chiefs -1.5 (-110)

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