NFL Week 7 Odds, Picks & Predictions: Chiefs vs. 49ers (2022)
We’re here to guide you through another weekend of NFL sports betting. Let’s take a look at our favorite odds, picks, and predictions for Chiefs vs. 49ers.
And check out our other NFL Week 7 game previews and picks:
- Falcons vs. Bengals
- Lions vs. Cowboys
- Colts vs. Titans
- Packers vs. Commanders
- Buccaneers vs. Panthers
- Giants vs. Jaguars
- Browns vs. Ravens
- Jets vs. Broncos
- Texans vs. Raiders
- Seahawks vs. Chargers
- Steelers vs. Dolphins
- Bears vs. Patriots
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NFL Week 7 Odds, Picks & Predictions: Chiefs vs. 49ers
In a rematch of Super Bowl LIV, both the Chiefs and 49ers look to rebound from their week six losses. Kansas City backers will cite Patrick Mahomes' career 11-3 record following a loss, but this winning percentage is no deviation from the young QB's all time record of 54-15.
Conversely, San Francisco has historically thrived in this spot. The 49ers duo of HC Kyle Shanahan and QB Jimmy Garopppolo are 3-0 ATS and SU as a home underdog, and they have covered six straight home games dating back to 2021.
The Chiefs are undoubtedly the better team, but this line stinks. San Francisco should find success running the ball, and their defense should be able to keep a lid on the Chiefs explosive offense.
49ers +3, Lean u48.5
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Phil Wood is a featured writer at BettingPros. For more from Phil, check out his archive and follow him @Phil_Wood_Jr.